EC number:1.1.1.395
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.395 |
|---|---|
| Description: | 3-alpha-hydroxybile acid CoA 3-dehydrogenase. |
| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.395 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.395 |
| KEGG Enzyme Link: | KEGG1.1.1.395 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.395 |
| ExPASy Enzyme Link: | ExPASy1.1.1.395 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.395 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.395 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.395 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.395 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.395 |
EC number:1.1.1.395
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55380 | a 3alpha-hydroxy bile acid CoA + NAD(+) = a 3-oxo bile acid CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression in Escherichia coli and characterization of a bile acid-inducible 3 alpha-hydroxysteroid dehydrogenase from Eubacterium sp. strain VPI 12708. | Mallonee DH, Lijewski MA, Hylemon PB | 1995 May | 7766153 |
| Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe. | Bhowmik S, Jones DH, Chiu HP, Park IH, Chiu HJ, Axelrod HL, Farr CL, Tien HJ, Agarwalla S, Lesley SA | 2014 Feb | 23836456 |
| RHEA:52596 | lithocholoyl-CoA + NAD(+) = 3-oxocholan-24-oyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe. | Bhowmik S, Jones DH, Chiu HP, Park IH, Chiu HJ, Axelrod HL, Farr CL, Tien HJ, Agarwalla S, Lesley SA | 2014 Feb | 23836456 |
| RHEA:52592 | deoxycholoyl-CoA + NAD(+) = 12alpha-hydroxy-3-oxocholan-24-oyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe. | Bhowmik S, Jones DH, Chiu HP, Park IH, Chiu HJ, Axelrod HL, Farr CL, Tien HJ, Agarwalla S, Lesley SA | 2014 Feb | 23836456 |
| RHEA:52588 | choloyl-CoA + NAD(+) = 7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe. | Bhowmik S, Jones DH, Chiu HP, Park IH, Chiu HJ, Axelrod HL, Farr CL, Tien HJ, Agarwalla S, Lesley SA | 2014 Feb | 23836456 |
| RHEA:52584 | chenodeoxycholoyl-CoA + NAD(+) = 7alpha-hydroxy-3-oxochol-24-oyl-CoA + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[c;H0;+0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[n+;H0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[C;H0;+0:6]1=[CH;+0:12]-[N;H0;+0:10](-[*:11])-[CH;+0:9]=[CH;+0:8]-[CH2;+0:7]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural and functional characterization of BaiA, an enzyme involved in secondary bile acid synthesis in human gut microbe. | Bhowmik S, Jones DH, Chiu HP, Park IH, Chiu HJ, Axelrod HL, Farr CL, Tien HJ, Agarwalla S, Lesley SA | 2014 Feb | 23836456 |