EC number:1.1.1.399

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.399
Description:2-oxoglutarate reductase.
Cath: 3.30.1330.90; 3.30.1370.170; 3.30.70.260; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.399
BRENDA Enzyme Link: BRENDA 1.1.1.399
KEGG Enzyme Link: KEGG1.1.1.399
BioCyc Enzyme Link: BioCyc 1.1.1.399
ExPASy Enzyme Link: ExPASy1.1.1.399
EC2PDB Enzyme Link: EC2PDB 1.1.1.399
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.399
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.399
IntEnz Enzyme Link: IntEnz 1.1.1.399
MEDLINE Enzyme Link: MEDLINE 1.1.1.399

EC number:1.1.1.399

MSA:

1.1.1.399;
Phylogenetic Tree:

1.1.1.399;
Uniprot:
M-CSA:
RHEA:49612 (R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.Zhao G, Winkler ME1996 Jan8550422
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD2015 Feb 2025406093
Purification and properties of alpha-ketoglutarate reductase from Micrococcus aerogenes.Lerud RF, Whiteley HR1971 May4396793
Purification and characterization of glutamic acid dehydrogenase and -ketoglutaric acid reductase from Peptococcus aerogenes.Johnson WM, Westlake DW1972 Jun4338318
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL2016 Mar 1826774271
Metabolite damage and its repair or pre-emption.Linster CL, Van Schaftingen E, Hanson AD2013 Feb23334546