EC number:1.1.1.62
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.62 | ||
|---|---|---|---|
| Description: | 17-beta-estradiol 17-dehydrogenase. | ||
| Alternative Name: |
Estrogen 17-oxidoreductase. 20-alpha-hydroxysteroid dehydrogenase. 17-beta-hydroxysteroid dehydrogenase. 17-beta-HSD. 17-beta-estradiol dehydrogenase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.20.20.10; 3.20.20.100; 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.62 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.62 |
| KEGG Enzyme Link: | KEGG1.1.1.62 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.62 |
| ExPASy Enzyme Link: | ExPASy1.1.1.62 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.62 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.62 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.62 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.62 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.62 |
| RHEA:24616 | 17beta-estradiol + NADP(+) = estrone + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sex hormone metabolism in prostate cancer cells during transition to an androgen-independent state. | Härkönen P, Törn S, Kurkela R, Porvari K, Pulkka A, Lindfors A, Isomaa V, Vihko P | 2003 Feb | 12574203 |
| Expression cloning of a novel estrogenic mouse 17 beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase (m17HSD7), previously described as a prolactin receptor-associated protein (PRAP) in rat. | Nokelainen P, Peltoketo H, Vihko R, Vihko P | 1998 Jul | 9658408 |
| Male pseudohermaphroditism caused by mutations of testicular 17 beta-hydroxysteroid dehydrogenase 3. | Geissler WM, Davis DL, Wu L, Bradshaw KD, Patel S, Mendonca BB, Elliston KO, Wilson JD, Russell DW, Andersson S | 1994 May | 8075637 |
| Aldo-keto Reductase 1B15 (AKR1B15): a mitochondrial human aldo-keto reductase with activity toward steroids and 3-keto-acyl-CoA conjugates. | Weber S, Salabei JK, Möller G, Kremmer E, Bhatnagar A, Adamski J, Barski OA | 2015 Mar 6 | 25577493 |
| Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer. | Byrns MC, Duan L, Lee SH, Blair IA, Penning TM | 2010 Feb 15 | 20036328 |
| Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. | Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K | 2000 Oct 1 | 10998348 |
| Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7. | Törn S, Nokelainen P, Kurkela R, Pulkka A, Menjivar M, Ghosh S, Coca-Prados M, Peltoketo H, Isomaa V, Vihko P | 2003 May 23 | 12732193 |
| RHEA:24612 | 17beta-estradiol + NAD(+) = estrone + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. | Wu L, Einstein M, Geissler WM, Chan HK, Elliston KO, Andersson S | 1993 Jun 15 | 8099587 |
| Biochemical Mechanisms and Catabolic Enzymes Involved in Bacterial Estrogen Degradation Pathways. | Chen YL, Yu CP, Lee TH, Goh KS, Chu KH, Wang PH, Ismail W, Shih CJ, Chiang YR | 2017 Jun 22 | 28552583 |
| Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. | Ohno S, Nishikawa K, Honda Y, Nakajin S | 2008 Feb | 17978863 |
| Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. | Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, Moore M, Palackal N, Ratnam K | 2000 Oct 1 | 10998348 |
| Characterization of structural and functional properties of human 17 beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis. | Puranen T, Poutanen M, Ghosh D, Vihko P, Vihko R | 1997 Jan | 8994190 |
| Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity. | Lukacik P, Keller B, Bunkoczi G, Kavanagh KL, Lee WH, Adamski J, Oppermann U | 2007 Mar 15 | 17067289 |
| Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase. | Luu-The V | 2001 Jan-Mar | 11384872 |