EC number:1.1.1.67

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.67
Description:Mannitol 2-dehydrogenase.
Alternative Name: Mannitol dehydrogenase.
Prosite: PDOC00751;
PDB:
PDBScop
Cath: 1.10.1040.10; 3.40.50.720;

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.67
BRENDA Enzyme Link: BRENDA 1.1.1.67
KEGG Enzyme Link: KEGG1.1.1.67
BioCyc Enzyme Link: BioCyc 1.1.1.67
ExPASy Enzyme Link: ExPASy1.1.1.67
EC2PDB Enzyme Link: EC2PDB 1.1.1.67
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.67
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.67
IntEnz Enzyme Link: IntEnz 1.1.1.67
MEDLINE Enzyme Link: MEDLINE 1.1.1.67

EC number:1.1.1.67

MSA:

1.1.1.67;
Phylogenetic Tree:

1.1.1.67;
Uniprot:
M-CSA:
RHEA:12084 D-mannitol + NAD(+) = D-fructose + H(+) + NADH
RULE(radius=1) ([*:1]-[CH;+0:2](-[*:3])-[*:4].[*:5]-[OH;+0:6]).[*:7]-[n+;H0:8]1:[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:1>>[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[CH;+0:10]-[CH2;+0:11]-[C;H0;+0:12](-[*:13])=[CH;+0:14]-1.[*:5]-[O;H0;+0:6]-[C;H0;+0:2](-[*:1])(-[*:3])-[*:4]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Enzymes of mannitol metabolism in the human pathogenic fungus Aspergillus fumigatus--kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications.Krahulec S, Armao GC, Klimacek M, Nidetzky B2011 Apr21299839
The oxyanion hole of Pseudomonas fluorescens mannitol 2-dehydrogenase: a novel structural motif for electrostatic stabilization in alcohol dehydrogenase active sites.Klimacek M, Nidetzky B2009 Dec 2319857201