EC number:1.1.1.69
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.1 Acting on the CH-OH group of donors |
| 1.1.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.1.1.69 | ||
|---|---|---|---|
| Description: | Gluconate 5-dehydrogenase. | ||
| Alternative Name: |
5-ketogluconate reductase. 5-ketogluconate 5-reductase. 5-keto-D-gluconate 5-reductase. | ||
| Prosite: | PDOC00060; | ||
| PDB: |
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| Cath: | 3.40.50.720; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.1.1.69 |
| BRENDA Enzyme Link: | BRENDA 1.1.1.69 |
| KEGG Enzyme Link: | KEGG1.1.1.69 |
| BioCyc Enzyme Link: | BioCyc 1.1.1.69 |
| ExPASy Enzyme Link: | ExPASy1.1.1.69 |
| EC2PDB Enzyme Link: | EC2PDB 1.1.1.69 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.1.1.69 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.1.1.69 |
| IntEnz Enzyme Link: | IntEnz 1.1.1.69 |
| MEDLINE Enzyme Link: | MEDLINE 1.1.1.69 |
| RHEA:23940 | D-gluconate + NAD(+) = 5-dehydro-D-gluconate + H(+) + NADH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural insight into the catalytic mechanism of gluconate 5-dehydrogenase from Streptococcus suis: Crystal structures of the substrate-free and quaternary complex enzymes. | Zhang Q, Peng H, Gao F, Liu Y, Cheng H, Thompson J, Gao GF | 2009 Feb | 19177572 |
| RHEA:23936 | D-gluconate + NADP(+) = 5-dehydro-D-gluconate + H(+) + NADPH |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Biochemical characterization and sequence analysis of the gluconate:NADP 5-oxidoreductase gene from Gluconobacter oxydans. | Klasen R, Bringer-Meyer S, Sahm H | 1995 May | 7751271 |
| Structural insight into the catalytic mechanism of gluconate 5-dehydrogenase from Streptococcus suis: Crystal structures of the substrate-free and quaternary complex enzymes. | Zhang Q, Peng H, Gao F, Liu Y, Cheng H, Thompson J, Gao GF | 2009 Feb | 19177572 |