EC number:1.1.1.95

Enzyme

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     1. Oxidoreductases
        1.1 Acting on the CH-OH group of donors
            1.1.1 With NAD+ or NADP+ as acceptor
ID:1.1.1.95
Description:Phosphoglycerate dehydrogenase.
Alternative Name: Phosphoglyceric acid dehydrogenase.
Phosphoglycerate oxidoreductase.
PGDH.
Glycerate-1,3-phosphate dehydrogenase.
Glycerate 3-phosphate dehydrogenase.
D-3-phosphoglycerate dehydrogenase.
Alpha-phosphoglycerate dehydrogenase.
Alpha-KG reductase.
3PHP reductase.
3-phosphoglyceric acid dehydrogenase.
3-phosphoglycerate dehydrogenase.
Prosite: PDOC00063;
PDB:
PDBScop
Cath: 3.30.1330.90; 3.30.70.260; 3.40.50.720;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.1.1.95
BRENDA Enzyme Link: BRENDA 1.1.1.95
KEGG Enzyme Link: KEGG1.1.1.95
BioCyc Enzyme Link: BioCyc 1.1.1.95
ExPASy Enzyme Link: ExPASy1.1.1.95
EC2PDB Enzyme Link: EC2PDB 1.1.1.95
ExplorEnz Enzyme Link: ExplorEnz 1.1.1.95
PRIAM enzyme-specific profiles Link: PRIAM 1.1.1.95
IntEnz Enzyme Link: IntEnz 1.1.1.95
MEDLINE Enzyme Link: MEDLINE 1.1.1.95

EC number:1.1.1.95

MSA:

1.1.1.95;
Phylogenetic Tree:

1.1.1.95;
Uniprot:
M-CSA:
RHEA:12641 3-phospho-D-glycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH
RULE(radius=1) [*:1]-[CH;+0:2](-[*:3])-[OH;+0:4].[*:5]-[n+;H0:6]1:[cH;+0:7]:[cH;+0:8]:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:1>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[CH;+0:8]-[CH2;+0:9]-[C;H0;+0:10](-[*:11])=[CH;+0:12]-1
Reaction
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References

TitleAuthorsDatePubMed ID
A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria.Zhao G, Winkler ME1996 Jan8550422
Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD2015 Feb 2025406093