EC number:1.10.5.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.10 Acting on diphenols and related substances as donors |
| 1.10.5 With a quinone or related compound as acceptor |
| ID: | 1.10.5.1 |
|---|---|
| Description: | Ribosyldihydronicotinamide dehydrogenase (quinone). |
| Alternative Name: |
Quinone reductase 2. QR2. NRH:quinone oxidoreductase 2. NQO(2). N-ribosyldihydronicotinamide dehydrogenase (quinone). |
| Cath: | 3.40.50.360; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.10.5.1 |
| BRENDA Enzyme Link: | BRENDA 1.10.5.1 |
| KEGG Enzyme Link: | KEGG1.10.5.1 |
| BioCyc Enzyme Link: | BioCyc 1.10.5.1 |
| ExPASy Enzyme Link: | ExPASy1.10.5.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.10.5.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.10.5.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.10.5.1 |
| IntEnz Enzyme Link: | IntEnz 1.10.5.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.10.5.1 |
| RHEA:12364 | 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[H+;H0:9].[O;H0;+0:10]=[C;H0;+0:11]1-[CH;+0:12]=[CH;+0:13]-[C;H0;+0:14](=[O;H0;+0:15])-[CH;+0:16]=[CH;+0:17]-1>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:10]-[c;H0;+0:11]1:[cH;+0:12]:[cH;+0:13]:[c;H0;+0:14](-[OH;+0:15]):[cH;+0:16]:[cH;+0:17]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase. | Wu K, Knox R, Sun XZ, Joseph P, Jaiswal AK, Zhang D, Deng PS, Chen S | 1997 Nov 15 | 9367528 |
| Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase) | Zhao Q, Yang XL, Holtzclaw WD, Talalay P | 1997 Mar 4 | 9050836 |
| Purification and properties of a flavoprotein catalyzing the oxidation of reduced ribosyl nicotinamide. | LIAO S, DULANEY JT, WILLIAMS-ASHMAN HG | 1962 Sep | 14465018 |