EC number:1.11.1.20

Enzyme

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     1. Oxidoreductases
        1.11 Acting on a peroxide as acceptor
            1.11.1 Peroxidases
ID:1.11.1.20
Description:Prostamide/prostaglandin F(2-alpha) synthase.
Alternative Name: TPGF synthase.
Prostamide/prostaglandin F synthase.
Prostamide/PGF synthase.
Prostamide F synthase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.11.1.20
BRENDA Enzyme Link: BRENDA 1.11.1.20
KEGG Enzyme Link: KEGG1.11.1.20
BioCyc Enzyme Link: BioCyc 1.11.1.20
ExPASy Enzyme Link: ExPASy1.11.1.20
EC2PDB Enzyme Link: EC2PDB 1.11.1.20
ExplorEnz Enzyme Link: ExplorEnz 1.11.1.20
PRIAM enzyme-specific profiles Link: PRIAM 1.11.1.20
IntEnz Enzyme Link: IntEnz 1.11.1.20
MEDLINE Enzyme Link: MEDLINE 1.11.1.20

EC number:1.11.1.20

MSA:

1.11.1.20;
Phylogenetic Tree:

1.11.1.20;
Uniprot:
M-CSA:
RHEA:28214 [thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-disulfide + prostaglandin F2alpha
RULE(radius=1) [*:1]-[O;H0;+0:2]-[O;H0;+0:3]-[*:4].[*:5]-[SH;+0:6].[*:7]-[SH;+0:8]>>([*:1]-[OH;+0:2].[*:4]-[OH;+0:3]).[*:5]-[S;H0;+0:6]-[S;H0;+0:8]-[*:7]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system.Yoshikawa K, Takei S, Hasegawa-Ishii S, Chiba Y, Furukawa A, Kawamura N, Hosokawa M, Woodward DF, Watanabe K, Shimada A2011 Jan 720950588
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K2008 Jan 1118006499
RHEA:26373 [thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-dithiol + prostamide H2
RULE(radius=1) ([*:1]-[OH;+0:2].[*:3]-[OH;+0:4]).[*:5]-[S;H0;+0:6]-[S;H0;+0:7]-[*:8]>>[*:1]-[O;H0;+0:2]-[O;H0;+0:4]-[*:3].[*:5]-[SH;+0:6].[*:8]-[SH;+0:7]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily.Moriuchi H, Koda N, Okuda-Ashitaka E, Daiyasu H, Ogasawara K, Toh H, Ito S, Woodward DF, Watanabe K2008 Jan 1118006499
Prostamides (prostaglandin-ethanolamides) and their pharmacology.Woodward DF, Liang Y, Krauss AH2008 Feb17721551
Enzymatic formation of prostamide F2alpha from anandamide involves a newly identified intermediate metabolite, prostamide H2.Yang W, Ni J, Woodward DF, Tang-Liu DD, Ling KH2005 Dec16150817