EC number:1.12.1.5
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.12 Acting on hydrogen as donor |
| 1.12.1 With NAD+ or NADP+ as acceptor |
| ID: | 1.12.1.5 |
|---|---|
| Description: | Hydrogen dehydrogenase (NAD(P)(+)). |
| Cath: | 3.40.30.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.12.1.5 |
| BRENDA Enzyme Link: | BRENDA 1.12.1.5 |
| KEGG Enzyme Link: | KEGG1.12.1.5 |
| BioCyc Enzyme Link: | BioCyc 1.12.1.5 |
| ExPASy Enzyme Link: | ExPASy1.12.1.5 |
| EC2PDB Enzyme Link: | EC2PDB 1.12.1.5 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.12.1.5 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.12.1.5 |
| IntEnz Enzyme Link: | IntEnz 1.12.1.5 |
| MEDLINE Enzyme Link: | MEDLINE 1.12.1.5 |
| RHEA:24636 | H2 + NAD(+) = H(+) + NADH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[H;H0;+0:9]-[H;H0;+0:10]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[H+;H0:9] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Hydrogenases I and II from Pyrococcus furiosus. | Ma K, Adams MW | 2001 | 11265463 |
| Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction. | Ma K, Weiss R, Adams MW | 2000 Apr | 10714990 |
| Effect of redox potential on the activation of the NAD-dependent hydrogenase from Alcaligenes eutrophus Z1. | Petrov RR, Utkin IB, Popov VO | 1989 Jan | 2643385 |
| Functional analysis by site-directed mutagenesis of the NAD(+)-reducing hydrogenase from Ralstonia eutropha. | Burgdorf T, De Lacey AL, Friedrich B | 2002 Nov | 12399498 |
| RHEA:18637 | H2 + NADP(+) = H(+) + NADPH |
| RULE(radius=1) | [*:1]-[n+;H0:2]1:[cH;+0:3]:[cH;+0:4]:[cH;+0:5]:[c;H0;+0:6](-[*:7]):[cH;+0:8]:1.[H;H0;+0:9]-[H;H0;+0:10]>>[*:1]-[N;H0;+0:2]1-[CH;+0:3]=[CH;+0:4]-[CH2;+0:5]-[C;H0;+0:6](-[*:7])=[CH;+0:8]-1.[H+;H0:9] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The NADP-reducing hydrogenase of Desulfovibrio fructosovorans: evidence for a native complex with hydrogen-dependent methyl-viologen-reducing activity. | de Luca G, de Philip P, Rousset M, Belaich JP, Dermoun Z | 1998 Jul 30 | 9703971 |
| Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor. | Ma K, Schicho RN, Kelly RM, Adams MW | 1993 Jun 1 | 8389482 |
| Characterization of hydrogenase from the hyperthermophilic archaebacterium, Pyrococcus furiosus. | Bryant FO, Adams MW | 1989 Mar 25 | 2538471 |
| Reinvestigation of the steady-state kinetics and physiological function of the soluble NiFe-hydrogenase I of Pyrococcus furiosus. | van Haaster DJ, Silva PJ, Hagedoorn PL, Jongejan JA, Hagen WR | 2008 Mar | 18156274 |
| Hydrogenases I and II from Pyrococcus furiosus. | Ma K, Adams MW | 2001 | 11265463 |
| Enzymes of hydrogen metabolism in Pyrococcus furiosus. | Silva PJ, van den Ban EC, Wassink H, Haaker H, de Castro B, Robb FT, Hagen WR | 2000 Nov | 11054105 |
| Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction. | Ma K, Weiss R, Adams MW | 2000 Apr | 10714990 |