EC number:1.12.5.1

Enzyme

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     1. Oxidoreductases
        1.12 Acting on hydrogen as donor
            1.12.5 With a quinone or similar compound as acceptor
ID:1.12.5.1
Description:Hydrogen:quinone oxidoreductase.
Alternative Name: Quinone-reactive Ni/Fe-hydrogenase.
Membrane-bound hydrogenase.
Hydrogen:menaquinone oxidoreductase.
Hydrogen-ubiquinone oxidoreductase.
Prosite: PDOC00400;
PDB:
PDBScop
4UE2 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575;
4UCW 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575;
3CUS 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575;
1YRQ 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025209; 8037588; 8054418; 8054419; 8025196; 8037575; 8025196; 8037575;
1CC1 8025199; 8025211; 8037578; 8037590; 8054420; 8054421;
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3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.12.5.1
BRENDA Enzyme Link: BRENDA 1.12.5.1
KEGG Enzyme Link: KEGG1.12.5.1
BioCyc Enzyme Link: BioCyc 1.12.5.1
ExPASy Enzyme Link: ExPASy1.12.5.1
EC2PDB Enzyme Link: EC2PDB 1.12.5.1
ExplorEnz Enzyme Link: ExplorEnz 1.12.5.1
PRIAM enzyme-specific profiles Link: PRIAM 1.12.5.1
IntEnz Enzyme Link: IntEnz 1.12.5.1
MEDLINE Enzyme Link: MEDLINE 1.12.5.1

EC number:1.12.5.1

MSA:

1.12.5.1;
Phylogenetic Tree:

1.12.5.1;
Uniprot:
M-CSA:
RHEA:18641 a menaquinone + H2 = a menaquinol
RULE(radius=1) [*:1]:[cH;+0:2]:[*:3]1:[c;H0;+0:4](:[*:5])-[C;H0;+0:6](=[O;H0;+0:7])-[C;H0;+0:8](-[*:9])=[CH;+0:10]-[C;H0;+0:11]-1=[O;H0;+0:12].[H;H0;+0:13]-[H;H0;+0:14]>>[*:1]:[c;H0;+0:2]1:[*:3](:[cH;+0:4]:[*:5]):[c;H0;+0:11](-[OH;+0:12]):[cH;+0:10]:[c;H0;+0:8](-[*:9]):[c;H0;+0:6]:1-[OH;+0:7]
Reaction
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References

TitleAuthorsDatePubMed ID
Identification of histidine residues in Wolinella succinogenes hydrogenase that are essential for menaquinone reduction by H2.Gross R, Simon J, Lancaster CR, Kröger A1998 Nov9822828
The quinone-reactive Ni/Fe-hydrogenase of Wolinella Succinogenes.Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchene A, Tripier D, Juvenal K1993 Jun 158319698
The quinone-reactive Ni/Fe-hydrogenase of Wolinella succinogenes.Dross F, Geisler V, Lenger R, Theis F, Krafft T, Fahrenholz F, Kojro E, Duchêne A, Tripier D, Juvenal K1992 May 151587288