EC number:1.13.11.25
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.25 |
|---|---|
| Description: | dioxygenase. |
| Alternative Name: |
Steroid 4,5-dioxygenase. 3-alkylcatechol 2,3-dioxygenase. |
| Cath: | 3.10.180.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.25 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.25 |
| KEGG Enzyme Link: | KEGG1.13.11.25 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.25 |
| ExPASy Enzyme Link: | ExPASy1.13.11.25 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.25 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.25 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.25 |
EC number:1.13.11.25
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:21352 | 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O2 = (1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H(+) |
| RULE(radius=1) | [*:1]-[c;H0;+0:2]1:[c;H0;+0:3](-[*:4]):[c;H0;+0:5](-[*:6]):[cH;+0:7]:[cH;+0:8]:[c;H0;+0:9]:1-[*:10].[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:12])-[C;H0;+0:9](-[*:10])=[CH;+0:8]-[CH;+0:7]=[C;H0;+0:5](-[*:6])-[C;H0;+0:3](-[*:4])=[O;H0;+0:11] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies of a ring-cleaving dioxygenase illuminate the role of cholesterol metabolism in the pathogenesis of Mycobacterium tuberculosis. | Yam KC, D'Angelo I, Kalscheuer R, Zhu H, Wang JX, Snieckus V, Ly LH, Converse PJ, Jacobs WR Jr, Strynadka N, Eltis LD | 2009 Mar | 19300498 |
| A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages. | Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD | 2007 Feb 6 | 17264217 |
| Gene encoding the hydrolase for the product of the meta-cleavage reaction in testosterone degradation by Comamonas testosteroni. | Horinouchi M, Hayashi T, Koshino H, Yamamoto T, Kudo T | 2003 Apr | 12676694 |