EC number:1.13.11.71
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.11 With incorporation of two atoms of oxygen |
| ID: | 1.13.11.71 |
|---|---|
| Description: | Carotenoid-9',10'-cleaving dioxygenase. |
| Alternative Name: |
Beta-carotene 9',10'-monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.11.71 |
| BRENDA Enzyme Link: | BRENDA 1.13.11.71 |
| KEGG Enzyme Link: | KEGG1.13.11.71 |
| BioCyc Enzyme Link: | BioCyc 1.13.11.71 |
| ExPASy Enzyme Link: | ExPASy1.13.11.71 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.11.71 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.11.71 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.11.71 |
| IntEnz Enzyme Link: | IntEnz 1.13.11.71 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.11.71 |
EC number:1.13.11.71
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:26389 | all-trans-beta-carotene + O2 = all-trans-10'-apo-beta-carotenal + beta-ionone |
| RULE(radius=1) | [*:1]-[CH;+0:2]=[C;H0;+0:3](-[*:4])-[*:5].[O;H0;+0:6]=[O;H0;+0:7]>>[*:4]-[C;H0;+0:3](-[*:5])=[O;H0;+0:7].[*:1]-[CH;+0:2]=[O;H0;+0:6] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Evidence for compartmentalization of mammalian carotenoid metabolism. | Palczewski G, Amengual J, Hoppel CL, von Lintig J | 2014 Oct | 25002123 |
| Two carotenoid oxygenases contribute to mammalian provitamin A metabolism. | Amengual J, Widjaja-Adhi MA, Rodriguez-Santiago S, Hessel S, Golczak M, Palczewski K, von Lintig J | 2013 Nov 22 | 24106281 |
| Production of β-apo-10'-carotenal from β-carotene by human β-carotene-9',10'-oxygenase expressed in E. coli. | Kim YS, Yeom SJ, Oh DK | 2011 Jun | 21302131 |
| A mitochondrial enzyme degrades carotenoids and protects against oxidative stress. | Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J | 2011 Mar | 21106934 |
| Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues. | Lindqvist A, He YG, Andersson S | 2005 Nov | 15983114 |
| Carotene oxygenases: a new family of double bond cleavage enzymes. | Wyss A | 2004 Jan | 14704328 |
| Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A. | Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J | 2001 Apr 27 | 11278918 |