EC number:1.13.12.17
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases) |
| 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed-function oxidases) |
| ID: | 1.13.12.17 | ||
|---|---|---|---|
| Description: | Dichloroarcyriaflavin A synthase. | ||
| Prosite: | PDOC00081; | ||
| PDB: |
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3D structure
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Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.13.12.17 |
| BRENDA Enzyme Link: | BRENDA 1.13.12.17 |
| KEGG Enzyme Link: | KEGG1.13.12.17 |
| BioCyc Enzyme Link: | BioCyc 1.13.12.17 |
| ExPASy Enzyme Link: | ExPASy1.13.12.17 |
| EC2PDB Enzyme Link: | EC2PDB 1.13.12.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.13.12.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.13.12.17 |
| IntEnz Enzyme Link: | IntEnz 1.13.12.17 |
| MEDLINE Enzyme Link: | MEDLINE 1.13.12.17 |
EC number:1.13.12.17
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:27314 | dichlorochromopyrrolate + 6 H(+) + 4 NADH + 4 O2 = 2 CO2 + dichloroarcyriaflavin A + 6 H2O + 4 NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12]1:[nH;+0:13]:[c;H0;+0:14](-[C;H0;+0:15](=[*:16])-[OH;+0:17]):[c;H0;+0:18](-[c;H0;+0:19](:[*:20]):[cH;+0:21]:[*:22]):[c;H0;+0:23]:1-[c;H0;+0:24](:[*:25]):[cH;+0:26]:[*:27].[H+;H0:28].[H+;H0:29].[H+;H0:30].[H+;H0:31].[H+;H0:32].[H+;H0:33].[O;H0;+0:34]=[O;H0;+0:35].[O;H0;+0:36]=[O;H0;+0:37]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:22]:[c;H0;+0:21]1:[c;H0;+0:19](:[*:20]):[c;H0;+0:18]2:[c;H0;+0:23](:[c;H0;+0:24](:[*:25]):[c;H0;+0:26]:1:[*:27])-[C;H0;+0:12](=[O;H0;+0:34])-[NH;+0:13]-[C;H0;+0:14]-2=[O;H0;+0:35].[*:9]=[C;H0;+0:10]=[O;H0;+0:11].[*:16]=[C;H0;+0:15]=[O;H0;+0:17].[OH2;+0:36].[OH2;+0:37] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. | Makino M, Sugimoto H, Shiro Y, Asamizu S, Onaka H, Nagano S | 2007 Jul 10 | 17606921 |
| Staurosporine and rebeccamycin aglycones are assembled by the oxidative action of StaP, StaC, and RebC on chromopyrrolic acid. | Howard-Jones AR, Walsh CT | 2006 Sep 20 | 16967980 |
| Combinatorial biosynthesis of antitumor indolocarbazole compounds. | Sánchez C, Zhu L, Braña AF, Salas AP, Rohr J, Méndez C, Salas JA | 2005 Jan 11 | 15625109 |