EC number:1.14.11.48
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor |
| ID: | 1.14.11.48 |
|---|---|
| Description: | Xanthine dioxygenase. |
| Alternative Name: |
Alpha-ketoglutarate-dependent xanthine hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.11.48 |
| BRENDA Enzyme Link: | BRENDA 1.14.11.48 |
| KEGG Enzyme Link: | KEGG1.14.11.48 |
| BioCyc Enzyme Link: | BioCyc 1.14.11.48 |
| ExPASy Enzyme Link: | ExPASy1.14.11.48 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.11.48 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.11.48 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.11.48 |
| IntEnz Enzyme Link: | IntEnz 1.14.11.48 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.11.48 |
EC number:1.14.11.48
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:43120 | 2-oxoglutarate + O2 + xanthine = CO2 + succinate + urate |
| RULE(radius=1) | [*:1]:[n;H0;+0:2]:[cH;+0:3]:[*:4].[*:5]=[C;H0;+0:6](-[OH;+0:7])-[C;H0;+0:8](=[*:9])-[*:10].[O;H0;+0:11]=[O;H0;+0:12]>>[*:1]:[nH;+0:2]:[c;H0;+0:3](:[*:4])=[O;H0;+0:11].[*:9]=[C;H0;+0:8](-[*:10])-[OH;+0:12].[*:5]=[C;H0;+0:6]=[O;H0;+0:7] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of active site variants of xanthine hydroxylase from Aspergillus nidulans. | Li M, Müller TA, Fraser BA, Hausinger RP | 2008 Feb 1 | 18036331 |
| Purification and characterization of the FeII- and alpha-ketoglutarate-dependent xanthine hydroxylase from Aspergillus nidulans. | Montero-Morán GM, Li M, Rendòn-Huerta E, Jourdan F, Lowe DJ, Stumpff-Kane AW, Feig M, Scazzocchio C, Hausinger RP | 2007 May 8 | 17429948 |
| Convergent evolution of hydroxylation mechanisms in the fungal kingdom: molybdenum cofactor-independent hydroxylation of xanthine via alpha-ketoglutarate-dependent dioxygenases. | Cultrone A, Scazzocchio C, Rochet M, Montero-Morán G, Drevet C, Fernández-Martín R | 2005 Jul | 15948966 |