EC number:1.14.12.1
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.1 |
|---|---|
| Description: | Anthranilate 1,2-dioxygenase (deaminating, decarboxylating). |
| Alternative Name: |
Anthranilic hydroxylase. Anthranilic acid hydroxylase. Anthranilate hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.1 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.1 |
| KEGG Enzyme Link: | KEGG1.14.12.1 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.1 |
| ExPASy Enzyme Link: | ExPASy1.14.12.1 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.1 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.1 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.1 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.1 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.1 |
EC number:1.14.12.1
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11076 | anthranilate + 3 H(+) + NADH + O2 = catechol + CO2 + NAD(+) + NH4(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12](:[*:13]):[c;H0;+0:14](:[*:15])-[NH2;+0:16].[H+;H0:17].[H+;H0:18].[H+;H0:19].[O;H0;+0:20]=[O;H0;+0:21]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:13]:[c;H0;+0:12](-[OH;+0:21]):[c;H0;+0:14](:[*:15])-[OH;+0:20].[*:9]=[C;H0;+0:10]=[O;H0;+0:11].[NH3;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID. | TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N | 1964 Jul | 14209949 |
| RHEA:11072 | anthranilate + 3 H(+) + NADPH + O2 = catechol + CO2 + NADP(+) + NH4(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12](:[*:13]):[c;H0;+0:14](:[*:15])-[NH2;+0:16].[H+;H0:17].[H+;H0:18].[H+;H0:19].[O;H0;+0:20]=[O;H0;+0:21]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:13]:[c;H0;+0:12](-[OH;+0:21]):[c;H0;+0:14](:[*:15])-[OH;+0:20].[*:9]=[C;H0;+0:10]=[O;H0;+0:11].[NH3;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| ENZYMATIC FORMATION OF CATECHOL FROM ANTHRANILIC ACID. | TANIUCHI H, HATANAKA M, KUNO S, HAYAISHI O, NAKAJIMA M, KURIHARA N | 1964 Jul | 14209949 |