EC number:1.14.12.11
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.11 |
|---|---|
| Description: | Toluene dioxygenase. |
| Alternative Name: |
Toluene 1,2-dioxygenase. |
| Cath: | 3.10.450.50; 3.90.380.10; 2.102.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.11 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.11 |
| KEGG Enzyme Link: | KEGG1.14.12.11 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.11 |
| ExPASy Enzyme Link: | ExPASy1.14.12.11 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.11 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.11 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.11 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.11 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.11 |
EC number:1.14.12.11
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:16737 | H(+) + NADH + O2 + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[H+;H0:16].[O;H0;+0:17]=[O;H0;+0:18]>>[*:9]-[C;H0;+0:10]1=[CH;+0:11]-[CH;+0:12]=[CH;+0:13]-[CH;+0:14](-[OH;+0:17])-[CH;+0:15]-1-[OH;+0:18].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structures of the multicomponent Rieske non-heme iron toluene 2,3-dioxygenase enzyme system. | Friemann R, Lee K, Brown EN, Gibson DT, Eklund H, Ramaswamy S | 2009 Jan | 19153463 |