EC number:1.14.12.12
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.12 | ||
|---|---|---|---|
| Description: | Naphthalene 1,2-dioxygenase. | ||
| Prosite: | PDOC00493; | ||
| PDB: |
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| Cath: | 3.10.450.50; 3.90.380.10; 2.102.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.12 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.12 |
| KEGG Enzyme Link: | KEGG1.14.12.12 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.12 |
| ExPASy Enzyme Link: | ExPASy1.14.12.12 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.12 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.12 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.12 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.12 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.12 |
EC number:1.14.12.12
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:19173 | H(+) + NADH + naphthalene + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]1:[*:10]:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH;+0:16]-[CH;+0:13]1-[CH;+0:12]=[CH;+0:11]-[*:10]:[*:9]-[CH;+0:14]-1-[OH;+0:17] |
| Reaction |  |
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| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. | Kauppi B, Lee K, Carredano E, Parales RE, Gibson DT, Eklund H, Ramaswamy S | 1998 May 15 | 9634695 |
| Naphthalene dioxygenase: purification and properties of a terminal oxygenase component. | Ensley BD, Gibson DT | 1983 Aug | 6874638 |
| Characterization of a naphthalene dioxygenase endowed with an exceptionally broad substrate specificity toward polycyclic aromatic hydrocarbons. | Jouanneau Y, Meyer C, Jakoncic J, Stojanoff V, Gaillard J | 2006 Oct 10 | 17014090 |
| Salicylate 5-hydroxylase from Ralstonia sp. strain U2: a monooxygenase with close relationships to and shared electron transport proteins with naphthalene dioxygenase. | Zhou NY, Al-Dulayymi J, Baird MS, Williams PA | 2002 Mar | 11872705 |
| Substrate specificity of naphthalene dioxygenase: effect of specific amino acids at the active site of the enzyme. | Parales RE, Lee K, Resnick SM, Jiang H, Lessner DJ, Gibson DT | 2000 Mar | 10692370 |