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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor

ID:	1.14.12.13
Description:	2-halobenzoate 1,2-dioxygenase.
Alternative Name:	2-chlorobenzoate 1,2-dioxygenase.
Cath:	3.10.450.50;

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UniProtKB Enzyme Link:	UniProtKB 1.14.12.13
BRENDA Enzyme Link:	BRENDA 1.14.12.13
KEGG Enzyme Link:	KEGG1.14.12.13
BioCyc Enzyme Link:	BioCyc 1.14.12.13
ExPASy Enzyme Link:	ExPASy1.14.12.13
EC2PDB Enzyme Link:	EC2PDB 1.14.12.13
ExplorEnz Enzyme Link:	ExplorEnz 1.14.12.13
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.12.13
IntEnz Enzyme Link:	IntEnz 1.14.12.13
MEDLINE Enzyme Link:	MEDLINE 1.14.12.13

RHEA:53736	a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[:9]:[c;H0;+0:10](-[;H0;+0:11]):[c;H0;+0:12](:[:13])-[C;H0;+0:14](=[:15])-[OH;+0:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[-;H0:11].[:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[:9]:[c;H0;+0:10](-[OH;+0:19]):[c;H0;+0:12](:[:13])-[OH;+0:18].[:15]=[C;H0;+0:14]=[O;H0;+0:16]
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Core-to-Core	More

Title	Authors	Date	PubMed ID
Cloning, nucleotide sequence, and expression of the plasmid-encoded genes for the two-component 2-halobenzoate 1,2-dioxygenase from Pseudomonas cepacia 2CBS.	Haak B, Fetzner S, Lingens F	1995 Feb	7530709
Purification and some properties of 2-halobenzoate 1,2-dioxygenase, a two-component enzyme system from Pseudomonas cepacia 2CBS.	Fetzner S, Müller R, Lingens F	1992 Jan	1370284

RHEA:21652	2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12](:[:13]):[c;H0;+0:14](:[:15])-[Cl;H0;+0:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[:13]:[c;H0;+0:12](-[OH;+0:19]):[c;H0;+0:14](:[:15])-[OH;+0:18].[:9]=[C;H0;+0:10]=[O;H0;+0:11].[Cl-;H0:16]
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Core-to-Core	More

Title	Authors	Date	PubMed ID
Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS.	Fetzner S, Müller R, Lingens F	1989 Nov	2610934