Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor
ID:1.14.12.13
Description:2-halobenzoate 1,2-dioxygenase.
Alternative Name: 2-chlorobenzoate 1,2-dioxygenase.
Cath: 3.10.450.50;

3D structure

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References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.12.13
BRENDA Enzyme Link: BRENDA 1.14.12.13
KEGG Enzyme Link: KEGG1.14.12.13
BioCyc Enzyme Link: BioCyc 1.14.12.13
ExPASy Enzyme Link: ExPASy1.14.12.13
EC2PDB Enzyme Link: EC2PDB 1.14.12.13
ExplorEnz Enzyme Link: ExplorEnz 1.14.12.13
PRIAM enzyme-specific profiles Link: PRIAM 1.14.12.13
IntEnz Enzyme Link: IntEnz 1.14.12.13
MEDLINE Enzyme Link: MEDLINE 1.14.12.13
MSA:

1.14.12.13;

Phylogenetic Tree:

1.14.12.13;

Uniprot:
M-CSA:
RHEA:53736 a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[c;H0;+0:10](-[*;H0;+0:11]):[c;H0;+0:12](:[*:13])-[C;H0;+0:14](=[*:15])-[OH;+0:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*-;H0:11].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](-[OH;+0:19]):[c;H0;+0:12](:[*:13])-[OH;+0:18].[*:15]=[C;H0;+0:14]=[O;H0;+0:16]
Reaction
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References

TitleAuthorsDatePubMed ID
Cloning, nucleotide sequence, and expression of the plasmid-encoded genes for the two-component 2-halobenzoate 1,2-dioxygenase from Pseudomonas cepacia 2CBS.Haak B, Fetzner S, Lingens F1995 Feb7530709
Purification and some properties of 2-halobenzoate 1,2-dioxygenase, a two-component enzyme system from Pseudomonas cepacia 2CBS.Fetzner S, Müller R, Lingens F1992 Jan1370284

RHEA:21652 2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12](:[*:13]):[c;H0;+0:14](:[*:15])-[Cl;H0;+0:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:13]:[c;H0;+0:12](-[OH;+0:19]):[c;H0;+0:14](:[*:15])-[OH;+0:18].[*:9]=[C;H0;+0:10]=[O;H0;+0:11].[Cl-;H0:16]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS.Fetzner S, Müller R, Lingens F1989 Nov2610934