EC Tree |
1. Oxidoreductases |
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
ID: | 1.14.12.13 |
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Description: | 2-halobenzoate 1,2-dioxygenase. |
Alternative Name: |
2-chlorobenzoate 1,2-dioxygenase. |
Cath: | 3.10.450.50; |
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.UniProtKB Enzyme Link: | UniProtKB 1.14.12.13 |
BRENDA Enzyme Link: | BRENDA 1.14.12.13 |
KEGG Enzyme Link: | KEGG1.14.12.13 |
BioCyc Enzyme Link: | BioCyc 1.14.12.13 |
ExPASy Enzyme Link: | ExPASy1.14.12.13 |
EC2PDB Enzyme Link: | EC2PDB 1.14.12.13 |
ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.13 |
PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.13 |
IntEnz Enzyme Link: | IntEnz 1.14.12.13 |
MEDLINE Enzyme Link: | MEDLINE 1.14.12.13 |
MSA: | |
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Phylogenetic Tree: | |
Uniprot: | |
M-CSA: |
RHEA:53736 | a 2-halobenzoate + H(+) + NADH + O2 = a halide anion + catechol + CO2 + NAD(+) |
RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[c;H0;+0:10](-[*;H0;+0:11]):[c;H0;+0:12](:[*:13])-[C;H0;+0:14](=[*:15])-[OH;+0:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*-;H0:11].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](-[OH;+0:19]):[c;H0;+0:12](:[*:13])-[OH;+0:18].[*:15]=[C;H0;+0:14]=[O;H0;+0:16] |
Reaction | ![]() |
Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Cloning, nucleotide sequence, and expression of the plasmid-encoded genes for the two-component 2-halobenzoate 1,2-dioxygenase from Pseudomonas cepacia 2CBS. | Haak B, Fetzner S, Lingens F | 1995 Feb | 7530709 |
Purification and some properties of 2-halobenzoate 1,2-dioxygenase, a two-component enzyme system from Pseudomonas cepacia 2CBS. | Fetzner S, Müller R, Lingens F | 1992 Jan | 1370284 |
RHEA:21652 | 2-chlorobenzoate + H(+) + NADH + O2 = catechol + chloride + CO2 + NAD(+) |
RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12](:[*:13]):[c;H0;+0:14](:[*:15])-[Cl;H0;+0:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:13]:[c;H0;+0:12](-[OH;+0:19]):[c;H0;+0:14](:[*:15])-[OH;+0:18].[*:9]=[C;H0;+0:10]=[O;H0;+0:11].[Cl-;H0:16] |
Reaction | ![]() |
Core-to-Core |
Title | Authors | Date | PubMed ID |
---|---|---|---|
Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS. | Fetzner S, Müller R, Lingens F | 1989 Nov | 2610934 |