EC number:1.14.12.17
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.17 |
|---|---|
| Description: | Nitric oxide dioxygenase. |
| Alternative Name: |
NOD. |
| Cath: | 1.10.490.10; 3.40.50.80; 2.40.30.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.17 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.17 |
| KEGG Enzyme Link: | KEGG1.14.12.17 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.17 |
| ExPASy Enzyme Link: | ExPASy1.14.12.17 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.17 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.17 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.17 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.17 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.17 |
EC number:1.14.12.17
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:19469 | NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[NH;+0:10].[*:11]=[NH;+0:12].[O;H0;+0:13]=[O;H0;+0:14].[O;H0;+0:15]=[O;H0;+0:16]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]=[N+;H0:10](-[OH;+0:13])-[OH;+0:14].[*:11]=[N+;H0:12](-[OH;+0:15])-[OH;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Constitutive and adaptive detoxification of nitric oxide in Escherichia coli. Role of nitric-oxide dioxygenase in the protection of aconitase. | Gardner PR, Costantino G, Salzman AL | 1998 Oct 9 | 9756889 |
| Nitric oxide dioxygenase: an enzymic function for flavohemoglobin. | Gardner PR, Gardner AM, Martin LA, Salzman AL | 1998 Sep 1 | 9724711 |
| Flavohemoglobin and nitric oxide detoxification in the human protozoan parasite Giardia intestinalis. | Mastronicola D, Testa F, Forte E, Bordi E, Pucillo LP, Sarti P, Giuffrè A | 2010 Sep 3 | 20691663 |
| Flavohemoglobin detoxifies nitric oxide in aerobic, but not anaerobic, Escherichia coli. Evidence for a novel inducible anaerobic nitric oxide-scavenging activity. | Gardner AM, Gardner PR | 2002 Mar 8 | 11751864 |
| Nitric-oxide dioxygenase activity and function of flavohemoglobins. sensitivity to nitric oxide and carbon monoxide inhibition. | Gardner PR, Gardner AM, Martin LA, Dou Y, Li T, Olson JS, Zhu H, Riggs AF | 2000 Oct 13 | 10922365 |