EC number:1.14.12.18
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.18 | ||
|---|---|---|---|
| Description: | Biphenyl 2,3-dioxygenase. | ||
| Alternative Name: |
Biphenyl dioxygenase. | ||
| Prosite: | PDOC00493; | ||
| PDB: |
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| Cath: | 3.10.450.50; 3.90.380.10; 2.102.10.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.18 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.18 |
| KEGG Enzyme Link: | KEGG1.14.12.18 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.18 |
| ExPASy Enzyme Link: | ExPASy1.14.12.18 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.18 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.18 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.18 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.18 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.18 |
EC number:1.14.12.18
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:18165 | biphenyl + H(+) + NADH + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[c;H0;+0:10](:[*:11])-[c;H0;+0:12]1:[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:[cH;+0:17]:1.[H+;H0:18].[O;H0;+0:19]=[O;H0;+0:20]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[C;H0;+0:12]1=[CH;+0:13]-[CH;+0:14]=[CH;+0:15]-[CH;+0:16](-[OH;+0:19])-[CH;+0:17]-1-[OH;+0:20] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural insight into the expanded PCB-degrading abilities of a biphenyl dioxygenase obtained by directed evolution. | Kumar P, Mohammadi M, Viger JF, Barriault D, Gomez-Gil L, Eltis LD, Bolin JT, Sylvestre M | 2011 Jan 14 | 21073881 |
| Characterization of two biphenyl dioxygenases for biphenyl/PCB degradation in A PCB degrader, Rhodococcus sp. strain RHA1. | Iwasaki T, Takeda H, Miyauchi K, Yamada T, Masai E, Fukuda M | 2007 Apr | 17420585 |
| Crystallization of the terminal oxygenase component of biphenyl dioxygenase derived from Rhodococcus sp. strain RHA1. | Nagarajan V, Sakurai N, Kubota M, Nonaka T, Nagumo H, Takeda H, Nishizaki T, Masai E, Fukuda M, Mitsui Y, Senda T | 2003 Aug | 14529495 |