EC number:1.14.12.25
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.25 |
|---|---|
| Description: | p-cumate 2,3-dioxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.25 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.25 |
| KEGG Enzyme Link: | KEGG1.14.12.25 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.25 |
| ExPASy Enzyme Link: | ExPASy1.14.12.25 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.25 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.25 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.25 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.25 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.25 |
EC number:1.14.12.25
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:42344 | H(+) + NADH + O2 + p-cumate = (2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[cH;+0:12]:[c;H0;+0:13](-[*:14]):[cH;+0:15]:[cH;+0:16]:1.[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:9]-[C;H0;+0:10]1=[CH;+0:11]-[CH;+0:12]=[C;H0;+0:13](-[*:14])-[CH;+0:15](-[OH;+0:18])-[CH;+0:16]-1-[OH;+0:19].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| p-cymene pathway in Pseudomonas putida: initial reactions. | DeFrank JJ, Ribbons DW | 1977 Mar | 845117 |
| Formation of indigo and related compounds from indolecarboxylic acids by aromatic acid-degrading bacteria: chromogenic reactions for cloning genes encoding dioxygenases that act on aromatic acids. | Eaton RW, Chapman PJ | 1995 Dec | 7592495 |
| p-Cymene pathway in Pseudomonas putida: selective enrichment of defective mutants by using halogenated substrate analogs. | Wigmore GJ, Ribbons DW | 1980 Aug | 7204334 |
| p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon. | Eaton RW | 1996 Mar | 8631713 |