EC number:1.14.12.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into the other donor |
| ID: | 1.14.12.7 |
|---|---|
| Description: | Phthalate 4,5-dioxygenase. |
| Alternative Name: |
Phthalate dioxygenase. PDO. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.12.7 |
| BRENDA Enzyme Link: | BRENDA 1.14.12.7 |
| KEGG Enzyme Link: | KEGG1.14.12.7 |
| BioCyc Enzyme Link: | BioCyc 1.14.12.7 |
| ExPASy Enzyme Link: | ExPASy1.14.12.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.12.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.12.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.12.7 |
| IntEnz Enzyme Link: | IntEnz 1.14.12.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.12.7 |
EC number:1.14.12.7
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17489 | H(+) + NADH + O2 + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:[c;H0;+0:15]:1-[*:16].[H+;H0:17].[O;H0;+0:18]=[O;H0;+0:19]>>[*:9]-[C;H0;+0:10]1=[CH;+0:11]-[CH;+0:12](-[OH;+0:18])-[CH;+0:13](-[OH;+0:19])-[CH;+0:14]=[C;H0;+0:15]-1-[*:16].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1 |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Phthalate dioxygenase. | Batie CJ, Ballou DP | 1990 | 2280719 |
| Chemistry of the catalytic conversion of phthalate into its cis-dihydrodiol during the reaction of oxygen with the reduced form of phthalate dioxygenase. | Tarasev M, Ballou DP | 2005 Apr 26 | 15835907 |
| Rates of the phthalate dioxygenase reaction with oxygen are dramatically increased by interactions with phthalate and phthalate oxygenase reductase. | Tarasev M, Rhames F, Ballou DP | 2004 Oct 12 | 15461452 |
| Purification and characterization of phthalate oxygenase and phthalate oxygenase reductase from Pseudomonas cepacia. | Batie CJ, LaHaie E, Ballou DP | 1987 Feb 5 | 3805038 |