EC number:1.14.13.10

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.13.10
Description:2,6-dihydroxypyridine 3-monooxygenase.
Cath: 3.30.9.60; 3.50.50.60;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.13.10
BRENDA Enzyme Link: BRENDA 1.14.13.10
KEGG Enzyme Link: KEGG1.14.13.10
BioCyc Enzyme Link: BioCyc 1.14.13.10
ExPASy Enzyme Link: ExPASy1.14.13.10
EC2PDB Enzyme Link: EC2PDB 1.14.13.10
ExplorEnz Enzyme Link: ExplorEnz 1.14.13.10
PRIAM enzyme-specific profiles Link: PRIAM 1.14.13.10
IntEnz Enzyme Link: IntEnz 1.14.13.10
MEDLINE Enzyme Link: MEDLINE 1.14.13.10

EC number:1.14.13.10

MSA:

1.14.13.10;
Phylogenetic Tree:

1.14.13.10;
Uniprot:
M-CSA:
RHEA:16917 2,6-dihydroxypyridine + H(+) + NADH + O2 = 2,3,6-trihydroxypyridine + H2O + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14]
Reaction
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References

TitleAuthorsDatePubMed ID
The bacterial oxidation of nicotine. 8. Synthesis of 2,3,6-trihydroxypyridine and accumulation and partial characterization of the product of 2,6-dihydroxypyridine oxidation.Holmes PE, Rittenberg SC, Knackmuss HJ1972 Dec 104636328
The bacterial oxidation of nicotine. VII. Partial purification and properties of 2,6-dihydroxypyridine oxidase.Holmes PE, Rittenberg SC1972 Dec 104344227