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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.13.101
Description:	Senecionine N-oxygenase.
Alternative Name:	Senecionine monooxygenase (N-oxide-forming).

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UniProtKB Enzyme Link:	UniProtKB 1.14.13.101
BRENDA Enzyme Link:	BRENDA 1.14.13.101
KEGG Enzyme Link:	KEGG1.14.13.101
BioCyc Enzyme Link:	BioCyc 1.14.13.101
ExPASy Enzyme Link:	ExPASy1.14.13.101
EC2PDB Enzyme Link:	EC2PDB 1.14.13.101
ExplorEnz Enzyme Link:	ExplorEnz 1.14.13.101
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.13.101
IntEnz Enzyme Link:	IntEnz 1.14.13.101
MEDLINE Enzyme Link:	MEDLINE 1.14.13.101

RHEA:11420	NADPH + O2 + senecionine = H2O + NADP(+) + senecionine N-oxide
RULE(radius=1)	[:1]-[N;H0;+0:2](-[:3])-[:4].[:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[O;H0;+0:13]=[O;H0;+0:14]>>[:1]-[N+;H0:2](-[:3])(-[:4])-[OH;+0:13].[:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:14]
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Title	Authors	Date	PubMed ID
The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids.	Lindigkeit R, Biller A, Buch M, Schiebel HM, Boppré M, Hartmann T	1997 May 1	9182998
Evolutionary recruitment of a flavin-dependent monooxygenase for the detoxification of host plant-acquired pyrrolizidine alkaloids in the alkaloid-defended arctiid moth Tyria jacobaeae.	Naumann C, Hartmann T, Ober D	2002 Apr 30	11972041