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1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.13.106
Description:	Epi-isozizaene 5-monooxygenase.
Alternative Name:	CYP170A1.
Cath:	1.10.600.10; 1.10.630.10;

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UniProtKB Enzyme Link:	UniProtKB 1.14.13.106
BRENDA Enzyme Link:	BRENDA 1.14.13.106
KEGG Enzyme Link:	KEGG1.14.13.106
BioCyc Enzyme Link:	BioCyc 1.14.13.106
ExPASy Enzyme Link:	ExPASy1.14.13.106
EC2PDB Enzyme Link:	EC2PDB 1.14.13.106
ExplorEnz Enzyme Link:	ExplorEnz 1.14.13.106
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.13.106
IntEnz Enzyme Link:	IntEnz 1.14.13.106
MEDLINE Enzyme Link:	MEDLINE 1.14.13.106

RHEA:32439	(+)-epi-isozizaene + 2 H(+) + 2 NADPH + 2 O2 = albaflavenone + 3 H2O + 2 NADP(+)
RULE(radius=1)	[:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[:9]-[CH2;+0:10]-[:11].[:12]-[N;H0;+0:13]1-[CH;+0:14]=[C;H0;+0:15](-[:16])-[CH2;+0:17]-[CH;+0:18]=[CH;+0:19]-1.[H+;H0:20].[H+;H0:21].[O;H0;+0:22]=[O;H0;+0:23].[O;H0;+0:24]=[O;H0;+0:25]>>[:9]-[C;H0;+0:10](-[:11])=[O;H0;+0:22].[:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[:12]-[n+;H0:13]1:[cH;+0:14]:[c;H0;+0:15](-[:16]):[cH;+0:17]:[cH;+0:18]:[cH;+0:19]:1.[OH2;+0:23].[OH2;+0:24].[OH2;+0:25]
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Title	Authors	Date	PubMed ID
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2).	Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE	2008 Mar 28	18234666