EC number:1.14.13.113
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.113 |
|---|---|
| Description: | FAD-dependent urate hydroxylase. |
| Alternative Name: |
Urate hydroxylase. FAD-dependent urate oxidase. |
| Cath: | 3.30.9.30; 3.50.50.60; 3.10.270.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.113 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.113 |
| KEGG Enzyme Link: | KEGG1.14.13.113 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.113 |
| ExPASy Enzyme Link: | ExPASy1.14.13.113 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.113 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.113 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.113 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.113 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.113 |
EC number:1.14.13.113
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:27329 | H(+) + NADH + O2 + urate = 5-hydroxyisourate + H2O + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[c;H0;+0:10]1:[nH;+0:11]:[c;H0;+0:12](=[*:13]):[c;H0;+0:14]2:[nH;+0:15]:[c;H0;+0:16](=[*:17]):[nH;+0:18]:[c;H0;+0:19]:2:[nH;+0:20]:1.[H+;H0:21].[O;H0;+0:22]=[O;H0;+0:23]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]=[C;H0;+0:10]1-[N;H0;+0:20]=[C;H0;+0:19]2-[NH;+0:18]-[C;H0;+0:16](=[*:17])-[NH;+0:15]-[C;H0;+0:14]-2(-[OH;+0:22])-[C;H0;+0:12](=[*:13])-[NH;+0:11]-1.[OH2;+0:23] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Microbial urate catabolism: characterization of HpyO, a non-homologous isofunctional isoform of the flavoprotein urate hydroxylase HpxO. | Michiel M, Perchat N, Perret A, Tricot S, Papeil A, Besnard M, de Berardinis V, Salanoubat M, Fischer C | 2012 Dec | 23760935 |
| Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. | O'Leary SE, Hicks KA, Ealick SE, Begley TP | 2009 Apr 14 | 19260710 |