EC number:1.14.13.114

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.13.114
Description:6-hydroxynicotinate 3-monooxygenase.
Alternative Name: HNA-3-monooxygenase.
6HNA monooxygenase.
Cath: 3.30.9.30; 3.50.50.60;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.13.114
BRENDA Enzyme Link: BRENDA 1.14.13.114
KEGG Enzyme Link: KEGG1.14.13.114
BioCyc Enzyme Link: BioCyc 1.14.13.114
ExPASy Enzyme Link: ExPASy1.14.13.114
EC2PDB Enzyme Link: EC2PDB 1.14.13.114
ExplorEnz Enzyme Link: ExplorEnz 1.14.13.114
PRIAM enzyme-specific profiles Link: PRIAM 1.14.13.114
IntEnz Enzyme Link: IntEnz 1.14.13.114
MEDLINE Enzyme Link: MEDLINE 1.14.13.114

EC number:1.14.13.114

MSA:

1.14.13.114;
Phylogenetic Tree:

1.14.13.114;
Uniprot:
M-CSA:
RHEA:27333 6-hydroxynicotinate + 2 H(+) + NADH + O2 = 2,5-dihydroxypyridine + CO2 + H2O + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]=[C;H0;+0:10](-[OH;+0:11])-[c;H0;+0:12](:[*:13]):[*:14].[H+;H0:15].[H+;H0:16].[O;H0;+0:17]=[O;H0;+0:18]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:13]:[c;H0;+0:12](:[*:14])-[OH;+0:17].[*:9]=[C;H0;+0:10]=[O;H0;+0:11].[OH2;+0:18]
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References

TitleAuthorsDatePubMed ID
Deciphering the genetic determinants for aerobic nicotinic acid degradation: the nic cluster from Pseudomonas putida KT2440.Jiménez JI, Canales A, Jiménez-Barbero J, Ginalski K, Rychlewski L, García JL, Díaz E2008 Aug 1218678916
Purification, characterization and gene cloning of 6-hydroxynicotinate 3-monooxygenase from Pseudomonas fluorescens TN5.Nakano H, Wieser M, Hurh B, Kawai T, Yoshida T, Yamane T, Nagasawa T1999 Feb10091591