EC number:1.14.13.148
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.148 |
|---|---|
| Description: | Trimethylamine monooxygenase. |
| Alternative Name: |
Flavin-containing monooxygenase 3. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.148 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.148 |
| KEGG Enzyme Link: | KEGG1.14.13.148 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.148 |
| ExPASy Enzyme Link: | ExPASy1.14.13.148 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.148 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.148 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.148 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.148 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.148 |
EC number:1.14.13.148
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:31979 | NADPH + O2 + trimethylamine = H2O + NADP(+) + trimethylamine N-oxide |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[N+;H0:2](-[*:3])(-[*:4])-[OH;+0:13].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Mutations of the flavin-containing monooxygenase gene (FMO3) cause trimethylaminuria, a defect in detoxication. | Treacy EP, Akerman BR, Chow LM, Youil R, Bibeau C, Lin J, Bruce AG, Knight M, Danks DM, Cashman JR, Forrest SM | 1998 May | 9536088 |
| Structural organization of the human flavin-containing monooxygenase 3 gene (FMO3), the favored candidate for fish-odor syndrome, determined directly from genomic DNA. | Dolphin CT, Riley JH, Smith RL, Shephard EA, Phillips IR | 1997 Dec 1 | 9417913 |
| Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase. | Chen Y, Patel NA, Crombie A, Scrivens JH, Murrell JC | 2011 Oct 25 | 22006322 |