EC number:1.14.13.160
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.160 |
|---|---|
| Description: | (2,2,3-trimethyl-5-oxocyclopent-3-enyl)acetyl-CoA 1,5-monooxygenase. |
| Alternative Name: |
OTEMO. 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase. 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase. |
| Cath: | 3.50.50.60; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.160 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.160 |
| KEGG Enzyme Link: | KEGG1.14.13.160 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.160 |
| ExPASy Enzyme Link: | ExPASy1.14.13.160 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.160 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.160 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.160 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.160 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.160 |
EC number:1.14.13.160
| MSA: | |
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| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:33015 | [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + H(+) + NADPH + O2 = [(2R)-3,3,4-trimethyl-6-oxo-3,6-dihydro-1H-pyran-2-yl]acetyl-CoA + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:4](=[*:5])-[*:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[CH2;+0:12]-[CH;+0:13]=[CH;+0:14]-1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:17]-[C;H0;+0:4](=[*:5])-[*:6].[*:7]-[n+;H0:8]1:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[OH2;+0:16] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Camphor revisited: involvement of a unique monooxygenase in metabolism of 2-oxo-delta 3-4,5,5-trimethylcyclopentenylacetic acid by Pseudomonas putida. | Ougham HJ, Taylor DG, Trudgill PW | 1983 Jan | 6848481 |
| Completing the series of BVMOs involved in camphor metabolism of Pseudomonas putida NCIMB 10007 by identification of the two missing genes, their functional expression in E. coli, and biochemical characterization. | Kadow M, Loschinski K, Sass S, Schmidt M, Bornscheuer UT | 2012 Oct | 22286514 |
| Cloning, Baeyer-Villiger biooxidations, and structures of the camphor pathway 2-oxo-Δ(3)-4,5,5-trimethylcyclopentenylacetyl-coenzyme A monooxygenase of Pseudomonas putida ATCC 17453. | Leisch H, Shi R, Grosse S, Morley K, Bergeron H, Cygler M, Iwaki H, Hasegawa Y, Lau PC | 2012 Apr | 22267661 |