EC number:1.14.13.163

Enzyme

Download
EC Tree
     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.13.163
Description:6-hydroxy-3-succinoylpyridine 3-monooxygenase.
Alternative Name: 6-hydroxy-3-succinoylpyridine hydroxylase.

3D structure

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.
PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.13.163
BRENDA Enzyme Link: BRENDA 1.14.13.163
KEGG Enzyme Link: KEGG1.14.13.163
BioCyc Enzyme Link: BioCyc 1.14.13.163
ExPASy Enzyme Link: ExPASy1.14.13.163
EC2PDB Enzyme Link: EC2PDB 1.14.13.163
ExplorEnz Enzyme Link: ExplorEnz 1.14.13.163
PRIAM enzyme-specific profiles Link: PRIAM 1.14.13.163
IntEnz Enzyme Link: IntEnz 1.14.13.163
MEDLINE Enzyme Link: MEDLINE 1.14.13.163

EC number:1.14.13.163

MSA:

1.14.13.163;
Phylogenetic Tree:

1.14.13.163;
Uniprot:
M-CSA:
RHEA:33927 4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 H(+) + 2 NADH + O2 = 2,5-dihydroxypyridine + H2O + 2 NAD(+) + succinate semialdehyde
RULE(radius=1) [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]1-[CH;+0:11]=[C;H0;+0:12](-[*:13])-[CH2;+0:14]-[CH;+0:15]=[CH;+0:16]-1.[*:17]:[c;H0;+0:18](:[*:19])-[C;H0;+0:20](-[*:21])=[*:22].[H+;H0:23].[H+;H0:24].[O;H0;+0:25]=[O;H0;+0:26]>>[*:21]-[CH;+0:20]=[*:22].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]-[n+;H0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[cH;+0:16]:1.[*:17]:[c;H0;+0:18](:[*:19])-[OH;+0:25].[OH2;+0:26]
Reaction
Core-to-Core More

References

TitleAuthorsDatePubMed ID
A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P2011 Nov 1121949128
A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16.Tang H, Wang S, Ma L, Meng X, Deng Z, Zhang D, Ma C, Xu P2008 Mar18203859