EC number:1.14.13.180

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.13.180
Description:Aklavinone 12-hydroxylase.
Alternative Name: Aklavinone 11-hydroxylase.
Cath: 3.30.9.50; 3.50.50.60; 3.40.30.120;

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.13.180
BRENDA Enzyme Link: BRENDA 1.14.13.180
KEGG Enzyme Link: KEGG1.14.13.180
BioCyc Enzyme Link: BioCyc 1.14.13.180
ExPASy Enzyme Link: ExPASy1.14.13.180
EC2PDB Enzyme Link: EC2PDB 1.14.13.180
ExplorEnz Enzyme Link: ExplorEnz 1.14.13.180
PRIAM enzyme-specific profiles Link: PRIAM 1.14.13.180
IntEnz Enzyme Link: IntEnz 1.14.13.180
MEDLINE Enzyme Link: MEDLINE 1.14.13.180

EC number:1.14.13.180

MSA:

1.14.13.180;
Phylogenetic Tree:

1.14.13.180;
Uniprot:
M-CSA:
RHEA:37835 aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14]
Reaction
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References

TitleAuthorsDatePubMed ID
Streptomyces peucetius daunorubicin biosynthesis gene, dnrF: sequence and heterologous expression.Filippini S, Solinas MM, Breme U, Schlüter MB, Gabellini D, Biamonti G, Colombo AL, Garofano L1995 Apr7773378
Characterization of aklavinone-11-hydroxylase from Streptomyces purpurascens.Niemi J, Wang Y, Airas K, Ylihonko K, Hakala J, Mäntsälä P1999 Feb 1010082933