EC number:1.14.13.190
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.190 |
|---|---|
| Description: | Ferruginol synthase. |
| Alternative Name: |
Miltiradiene oxidase. CYP76AH1. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.190 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.190 |
| KEGG Enzyme Link: | KEGG1.14.13.190 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.190 |
| ExPASy Enzyme Link: | ExPASy1.14.13.190 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.190 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.190 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.190 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.190 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.190 |
EC number:1.14.13.190
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:48080 | abietatriene + H(+) + NADPH + O2 = ferruginol + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Towards Elucidating Carnosic Acid Biosynthesis in Lamiaceae: Functional Characterization of the Three First Steps of the Pathway in Salvia fruticosa and Rosmarinus officinalis. | Božić D, Papaefthimiou D, Brückner K, de Vos RC, Tsoleridis CA, Katsarou D, Papanikolaou A, Pateraki I, Chatzopoulou FM, Dimitriadou E, Kostas S, Manzano D, Scheler U, Ferrer A, Tissier A, Makris AM, Kampranis SC, Kanellis AK | 2015 | 26020634 |
| Characterization of CYP76AH4 clarifies phenolic diterpenoid biosynthesis in the Lamiaceae. | Zi J, Peters RJ | 2013 Nov 28 | 24108414 |
| CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts. | Guo J, Zhou YJ, Hillwig ML, Shen Y, Yang L, Wang Y, Zhang X, Liu W, Peters RJ, Chen X, Zhao ZK, Huang L | 2013 Jul 16 | 23812755 |