EC number:1.14.13.211
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.211 |
|---|---|
| Description: | Rifampicin monooxygenase. |
| Alternative Name: |
RIF-O. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.211 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.211 |
| KEGG Enzyme Link: | KEGG1.14.13.211 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.211 |
| ExPASy Enzyme Link: | ExPASy1.14.13.211 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.211 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.211 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.211 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.211 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.211 |
EC number:1.14.13.211
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:48988 | NADH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NAD(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]=[CH;+0:11]-[c;H0;+0:12]1:[c;H0;+0:13](-[OH;+0:14]):[*:15]:[*:16]:[c;H0;+0:17](-[*:18]):[c;H0;+0:19]:1-[*:20].[O;H0;+0:21]=[O;H0;+0:22]>>[*:9]-[N;H0;+0:10](-[OH;+0:21])-[CH;+0:11]=[C;H0;+0:12]1-[C;H0;+0:13](=[O;H0;+0:14])-[*:15]:[*:16]-[C;H0;+0:17](-[*:18])=[C;H0;+0:19]-1-[*:20].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:22] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic. | Andersen SJ, Quan S, Gowan B, Dabbs ER | 1997 Jan | 8980786 |
| Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance. | Hoshino Y, Fujii S, Shinonaga H, Arai K, Saito F, Fukai T, Satoh H, Miyazaki Y, Ishikawa J | 2010 Jan | 19942945 |
| RHEA:46596 | NADPH + O2 + rifampicin = 2'-N-hydroxyrifampicin + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2]1=[CH;+0:3]-[N;H0;+0:4](-[*:5])-[CH;+0:6]=[CH;+0:7]-[CH2;+0:8]-1.[*:9]-[N;H0;+0:10]=[CH;+0:11]-[c;H0;+0:12]1:[c;H0;+0:13](-[OH;+0:14]):[*:15]:[*:16]:[c;H0;+0:17](-[*:18]):[c;H0;+0:19]:1-[*:20].[O;H0;+0:21]=[O;H0;+0:22]>>[*:9]-[N;H0;+0:10](-[OH;+0:21])-[CH;+0:11]=[C;H0;+0:12]1-[C;H0;+0:13](=[O;H0;+0:14])-[*:15]:[*:16]-[C;H0;+0:17](-[*:18])=[C;H0;+0:19]-1-[*:20].[*:1]-[c;H0;+0:2]1:[cH;+0:3]:[n+;H0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:22] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Monooxygenase-like sequence of a Rhodococcus equi gene conferring increased resistance to rifampin by inactivating this antibiotic. | Andersen SJ, Quan S, Gowan B, Dabbs ER | 1997 Jan | 8980786 |
| Monooxygenation of rifampicin catalyzed by the rox gene product of Nocardia farcinica: structure elucidation, gene identification and role in drug resistance. | Hoshino Y, Fujii S, Shinonaga H, Arai K, Saito F, Fukai T, Satoh H, Miyazaki Y, Ishikawa J | 2010 Jan | 19942945 |