EC number:1.14.13.215
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.215 |
|---|---|
| Description: | Protoasukamycin 4-monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.215 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.215 |
| KEGG Enzyme Link: | KEGG1.14.13.215 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.215 |
| ExPASy Enzyme Link: | ExPASy1.14.13.215 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.215 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.215 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.215 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.215 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.215 |
EC number:1.14.13.215
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:49044 | H(+) + NADH + O2 + protoasukamycin = 4-hydroxyprotoasukamycin + H2O + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[c;H0;+0:12](-[*:13]):[cH;+0:14]:[cH;+0:15]:[c;H0;+0:16]:1-[OH;+0:17].[H+;H0:18].[O;H0;+0:19]=[O;H0;+0:20]>>[*:9]-[C;H0;+0:10]1=[CH;+0:11]-[C;H0;+0:12](-[*:13])(-[OH;+0:19])-[CH;+0:14]=[CH;+0:15]-[C;H0;+0:16]-1=[O;H0;+0:17].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:20] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Tandem enzymatic oxygenations in biosynthesis of epoxyquinone pharmacophore of manumycin-type metabolites. | Rui Z, Sandy M, Jung B, Zhang W | 2013 Jul 25 | 23890006 |