EC number:1.14.13.223

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.13.223
Description:3-hydroxy-4-methyl-anthranilyl-[aryl-carrier protein] 5-monooxygenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.13.223
BRENDA Enzyme Link: BRENDA 1.14.13.223
KEGG Enzyme Link: KEGG1.14.13.223
BioCyc Enzyme Link: BioCyc 1.14.13.223
ExPASy Enzyme Link: ExPASy1.14.13.223
EC2PDB Enzyme Link: EC2PDB 1.14.13.223
ExplorEnz Enzyme Link: ExplorEnz 1.14.13.223
PRIAM enzyme-specific profiles Link: PRIAM 1.14.13.223
IntEnz Enzyme Link: IntEnz 1.14.13.223
MEDLINE Enzyme Link: MEDLINE 1.14.13.223

EC number:1.14.13.223

MSA:

1.14.13.223;
Phylogenetic Tree:

1.14.13.223;
Uniprot:
M-CSA:
RHEA:49716 3-hydroxy-4-methylanthranilyl-[aryl-carrier protein] + H(+) + NADH + O2 = 3,5-dihydroxy-4-methylanthranilyl-[aryl-carrier protein] + H2O + NAD(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14]
Reaction
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References

TitleAuthorsDatePubMed ID
A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin.Giessen TW, Kraas FI, Marahiel MA2011 Jun 2821612226