EC number:1.14.13.225
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.225 |
|---|---|
| Description: | F-actin monooxygenase. |
| Cath: | 1.10.418.10; 3.50.50.70; 2.10.110.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.225 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.225 |
| KEGG Enzyme Link: | KEGG1.14.13.225 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.225 |
| ExPASy Enzyme Link: | ExPASy1.14.13.225 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.225 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.225 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.225 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.225 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.225 |
EC number:1.14.13.225
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24722 | H(+) + L-methionyl(44)-[F-actin] + NADPH + O2 = H2O + L-methionyl(44)-(R)-S-oxide-[F-actin] + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[S;H0;+0:10]-[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:9]-[S;H0;+0:10](-[*:11])=[O;H0;+0:13].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics. | Hung RJ, Spaeth CS, Yesilyurt HG, Terman JR | 2013 Dec | 24212093 |
| Direct redox regulation of F-actin assembly and disassembly by Mical. | Hung RJ, Pak CW, Terman JR | 2011 Dec 23 | 22116028 |
| Mical links semaphorins to F-actin disassembly. | Hung RJ, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, Huang Z, van Berkel WJ, Terman JR | 2010 Feb 11 | 20148037 |
| RHEA:49676 | H(+) + L-methionyl(47)-[F-actin] + NADPH + O2 = H2O + L-methionyl(47)-(R)-S-oxide-[F-actin] + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[S;H0;+0:10]-[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:9]-[S;H0;+0:10](-[*:11])=[O;H0;+0:13].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics. | Hung RJ, Spaeth CS, Yesilyurt HG, Terman JR | 2013 Dec | 24212093 |
| Direct redox regulation of F-actin assembly and disassembly by Mical. | Hung RJ, Pak CW, Terman JR | 2011 Dec 23 | 22116028 |
| Mical links semaphorins to F-actin disassembly. | Hung RJ, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, Huang Z, van Berkel WJ, Terman JR | 2010 Feb 11 | 20148037 |
| RHEA:51308 | H(+) + L-methionyl-[F-actin] + NADPH + O2 = H2O + L-methionyl-(R)-S-oxide-[F-actin] + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[S;H0;+0:10]-[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:9]-[S;H0;+0:10](-[*:11])=[O;H0;+0:13].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics. | Hung RJ, Spaeth CS, Yesilyurt HG, Terman JR | 2013 Dec | 24212093 |
| Direct redox regulation of F-actin assembly and disassembly by Mical. | Hung RJ, Pak CW, Terman JR | 2011 Dec 23 | 22116028 |
| Mical links semaphorins to F-actin disassembly. | Hung RJ, Yazdani U, Yoon J, Wu H, Yang T, Gupta N, Huang Z, van Berkel WJ, Terman JR | 2010 Feb 11 | 20148037 |