EC number:1.14.13.231
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.231 |
|---|---|
| Description: | Tetracycline 11a-monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.231 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.231 |
| KEGG Enzyme Link: | KEGG1.14.13.231 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.231 |
| ExPASy Enzyme Link: | ExPASy1.14.13.231 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.231 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.231 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.231 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.231 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.231 |
EC number:1.14.13.231
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50004 | H(+) + NADPH + O2 + tetracycline = 11a-hydroxytetracycline + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[OH;+0:3])=[C;H0;+0:4](-[*:5])-[*:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[CH2;+0:12]-[CH;+0:13]=[CH;+0:14]-1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[C;H0;+0:2](=[O;H0;+0:3])-[C;H0;+0:4](-[*:5])(-[*:6])-[OH;+0:16].[*:7]-[n+;H0:8]1:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[OH2;+0:17] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Structural basis for a new tetracycline resistance mechanism relying on the TetX monooxygenase. | Volkers G, Palm GJ, Weiss MS, Wright GD, Hinrichs W | 2011 Apr 6 | 21402075 |
| Tigecycline is modified by the flavin-dependent monooxygenase TetX. | Moore IF, Hughes DW, Wright GD | 2005 Sep 6 | 16128584 |
| TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics. | Yang W, Moore IF, Koteva KP, Bareich DC, Hughes DW, Wright GD | 2004 Dec 10 | 15452119 |