EnzyMine

Download

EC Tree

1. Oxidoreductases

1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor

ID:	1.14.13.233
Description:	4-hydroxy-6-methylpretetramide 12a-monooxygenase.

Click one PDB to see exact 3D structure provided by NGL.

Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.

PDB	Click once to unfold,double click to fold.

UniProtKB Enzyme Link:	UniProtKB 1.14.13.233
BRENDA Enzyme Link:	BRENDA 1.14.13.233
KEGG Enzyme Link:	KEGG1.14.13.233
BioCyc Enzyme Link:	BioCyc 1.14.13.233
ExPASy Enzyme Link:	ExPASy1.14.13.233
EC2PDB Enzyme Link:	EC2PDB 1.14.13.233
ExplorEnz Enzyme Link:	ExplorEnz 1.14.13.233
PRIAM enzyme-specific profiles Link:	PRIAM 1.14.13.233
IntEnz Enzyme Link:	IntEnz 1.14.13.233
MEDLINE Enzyme Link:	MEDLINE 1.14.13.233

RHEA:50356	4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + H2O + NADP(+)
RULE(radius=1)	[:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[:9]-[c;H0;+0:10]1:[c;H0;+0:11](-[:12]):[c;H0;+0:13](-[OH;+0:14]):[c;H0;+0:15]2:[cH;+0:16]:[:17]:[:18]:[c;H0;+0:19](-[OH;+0:20]):[c;H0;+0:21]:2:[c;H0;+0:22]:1-[OH;+0:23].[O;H0;+0:24]=[O;H0;+0:25]>>[:9]-[C;H0;+0:10]1=[C;H0;+0:11](-[:12])-[C;H0;+0:13](=[O;H0;+0:14])-[CH;+0:15]2-[CH2;+0:16]-[:17]:[:18]-[C;H0;+0:19](=[O;H0;+0:20])-[C;H0;+0:21]-2(-[OH;+0:24])-[C;H0;+0:22]-1=[O;H0;+0:23].[:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:25]
Reaction
Core-to-Core	More
Core-to-Core	More

Title	Authors	Date	PubMed ID
Identifying the minimal enzymes required for anhydrotetracycline biosynthesis.	Zhang W, Watanabe K, Cai X, Jung ME, Tang Y, Zhan J	2008 May 14	18422316