EC number:1.14.13.234
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.234 |
|---|---|
| Description: | 12-dehydrotetracycline 5-monooxygenase. |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.234 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.234 |
| KEGG Enzyme Link: | KEGG1.14.13.234 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.234 |
| ExPASy Enzyme Link: | ExPASy1.14.13.234 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.234 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.234 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.234 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.234 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.234 |
EC number:1.14.13.234
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:50388 | 5a,11a-dehydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrooxytetracycline + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[*:3].[*:4]-[N;H0;+0:5]1-[CH;+0:6]=[C;H0;+0:7](-[*:8])-[CH2;+0:9]-[CH;+0:10]=[CH;+0:11]-1.[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[CH;+0:2](-[*:3])-[OH;+0:13].[*:4]-[n+;H0:5]1:[cH;+0:6]:[c;H0;+0:7](-[*:8]):[cH;+0:9]:[cH;+0:10]:[cH;+0:11]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| A new family of tetracycline precursors. N-demethylanhydrotetracyclines. | Miller PA, Saturnelli A, Martin JH, Itscher LA, Bohonos N | 1964 Jun 15 | 4959040 |
| Isolation of pure anhydrotetracycline oxygenase from Streptomyces aureofaciens. | Vancurová I, Volc J, Flieger M, Neuzil J, Novotná J, Vlach J, Bĕhal V | 1988 Jul 1 | 3138982 |
| Cloning and heterologous expression in Streptomyces lividans of Streptomyces rimosus genes involved in oxytetracycline biosynthesis. | Binnie C, Warren M, Butler MJ | 1989 Feb | 2914874 |
| Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. | Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y | 2013 May 15 | 23621493 |