EC number:1.14.13.236
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.236 |
|---|---|
| Description: | Toluene 4-monooxygenase. |
| Alternative Name: |
TMO. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.236 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.236 |
| KEGG Enzyme Link: | KEGG1.14.13.236 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.236 |
| ExPASy Enzyme Link: | ExPASy1.14.13.236 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.236 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.236 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.236 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.236 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.236 |
EC number:1.14.13.236
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:41380 | H(+) + NADH + O2 + toluene = 4-methylphenol + H2O + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Atomic picture of ligand migration in toluene 4-monooxygenase. | Hosseini A, Brouk M, Lucas MF, Glaser F, Fishman A, Guallar V | 2015 Jan 22 | 24798294 |
| Crystallographic analysis of active site contributions to regiospecificity in the diiron enzyme toluene 4-monooxygenase. | Bailey LJ, Acheson JF, McCoy JG, Elsen NL, Phillips GN Jr, Fox BG | 2012 Feb 14 | 22264099 |
| Toluene-4-monooxygenase, a three-component enzyme system that catalyzes the oxidation of toluene to p-cresol in Pseudomonas mendocina KR1. | Whited GM, Gibson DT | 1991 May | 2019563 |
| Geometric and electronic structure studies of the binuclear nonheme ferrous active site of toluene-4-monooxygenase: parallels with methane monooxygenase and insight into the role of the effector proteins in O2 activation. | Schwartz JK, Wei PP, Mitchell KH, Fox BG, Solomon EI | 2008 Jun 4 | 18479085 |
| Solution structure of the toluene 4-monooxygenase effector protein (T4moD). | Hemmi H, Studts JM, Chae YK, Song J, Markley JL, Fox BG | 2001 Mar 27 | 11297417 |