EC number:1.14.13.239
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.239 |
|---|---|
| Description: | Carnitine monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.239 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.239 |
| KEGG Enzyme Link: | KEGG1.14.13.239 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.239 |
| ExPASy Enzyme Link: | ExPASy1.14.13.239 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.239 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.239 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.239 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.239 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.239 |
EC number:1.14.13.239
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55396 | (R)-carnitine + H(+) + NADH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NAD(+) + trimethylamine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[N+;H0:3](-[*:4])(-[*:5])-[*:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[CH2;+0:12]-[CH;+0:13]=[CH;+0:14]-1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[CH;+0:2]=[O;H0;+0:16].[*:4]-[N;H0;+0:3](-[*:5])-[*:6].[*:7]-[n+;H0:8]1:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[OH2;+0:17] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| L-carnitine via enzyme-catalyzed oxidative kinetic resolution. | Ditullio D, Anderson D, Chen CS, Sih CJ | 1994 Jun | 8000862 |
| γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. | Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL | 2014 Nov 4 | 25440057 |
| Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. | Zhu Y, Jameson E, Crosatti M, Schäfer H, Rajakumar K, Bugg TD, Chen Y | 2014 Mar 18 | 24591617 |
| RHEA:55368 | (R)-carnitine + H(+) + NADPH + O2 = (3R)-3-hydroxy-4-oxobutanoate + H2O + NADP(+) + trimethylamine |
| RULE(radius=1) | [*:1]-[CH2;+0:2]-[N+;H0:3](-[*:4])(-[*:5])-[*:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[CH2;+0:12]-[CH;+0:13]=[CH;+0:14]-1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[CH;+0:2]=[O;H0;+0:16].[*:4]-[N;H0;+0:3](-[*:5])-[*:6].[*:7]-[n+;H0:8]1:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[OH2;+0:17] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| L-carnitine via enzyme-catalyzed oxidative kinetic resolution. | Ditullio D, Anderson D, Chen CS, Sih CJ | 1994 Jun | 8000862 |
| γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. | Koeth RA, Levison BS, Culley MK, Buffa JA, Wang Z, Gregory JC, Org E, Wu Y, Li L, Smith JD, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL | 2014 Nov 4 | 25440057 |
| Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. | Zhu Y, Jameson E, Crosatti M, Schäfer H, Rajakumar K, Bugg TD, Chen Y | 2014 Mar 18 | 24591617 |