EC number:1.14.13.240
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.240 |
|---|---|
| Description: | 2-polyprenylphenol 6-hydroxylase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.240 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.240 |
| KEGG Enzyme Link: | KEGG1.14.13.240 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.240 |
| ExPASy Enzyme Link: | ExPASy1.14.13.240 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.240 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.240 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.240 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.240 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.240 |
EC number:1.14.13.240
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:55892 | a 2-all-trans-polyprenylphenol + H(+) + NADPH + O2 = a 3-(all-trans-polyprenyl)benzene-1,2-diol + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. | Young IG, McCann LM, Stroobant P, Gibson F | 1971 Mar | 4323297 |
| Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions. | Pelosi L, Ducluzeau AL, Loiseau L, Barras F, Schneider D, Junier I, Pierrel F | 2016 Jul-Aug | 27822549 |
| ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation. | Hajj Chehade M, Loiseau L, Lombard M, Pecqueur L, Ismail A, Smadja M, Golinelli-Pimpaneau B, Mellot-Draznieks C, Hamelin O, Aussel L, Kieffer-Jaquinod S, Labessan N, Barras F, Fontecave M, Pierrel F | 2013 Jul 5 | 23709220 |
| Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene. | Kwon O, Kotsakis A, Meganathan R | 2000 May 15 | 10802164 |
| RHEA:27790 | 2-all-trans-octaprenylphenol + H(+) + NADPH + O2 = 3-(all-trans-octaprenyl)benzene-1,2-diol + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[c;H0;+0:10](-[CH2;+0:11]-[CH;+0:12]=[C;H0;+0:13](-[*:14])-[*:15]-[CH2;+0:16]-[CH;+0:17]=[C;H0;+0:18](-[CH3;+0:19])-[CH2;+0:20]-[CH2;+0:21]-[CH;+0:22]=[C;H0;+0:23](-[CH3;+0:24])-[CH2;+0:25]-[CH2;+0:26]-[CH;+0:27]=[C;H0;+0:28](-[CH3;+0:29])-[CH2;+0:30]-[CH2;+0:31]-[CH;+0:32]=[C;H0;+0:33](-[CH3;+0:34])-[CH2;+0:35]-[CH2;+0:36]-[CH;+0:37]=[C;H0;+0:38](-[CH3;+0:39])-[CH2;+0:40]-[CH2;+0:41]-[CH;+0:42]=[C;H0;+0:43](-[CH3;+0:44])-[CH2;+0:45]-[CH2;+0:46]-[CH;+0:47]=[C;H0;+0:48](-[CH3;+0:49])-[CH3;+0:50]):[cH;+0:51]:[cH;+0:52]:[*:53].[H+;H0:54].[O;H0;+0:55]=[O;H0;+0:56]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](-[OH;+0:56]):[c;H0;+0:11](-[CH2;+0:12]-[C+;H0:13]1(-[*:14])=[C;H0;+0:16](-[CH3;+0:17])-[*:15]-1):[cH;+0:52]:[*:53].[OH2;+0:55] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization and genetic analysis of mutant strains of Escherichia coli K-12 accumulating the biquinone precursors 2-octaprenyl-6-methoxy-1,4-benzoquinone and 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone. | Young IG, McCann LM, Stroobant P, Gibson F | 1971 Mar | 4323297 |
| Evolution of Ubiquinone Biosynthesis: Multiple Proteobacterial Enzymes with Various Regioselectivities To Catalyze Three Contiguous Aromatic Hydroxylation Reactions. | Pelosi L, Ducluzeau AL, Loiseau L, Barras F, Schneider D, Junier I, Pierrel F | 2016 Jul-Aug | 27822549 |
| ubiI, a new gene in Escherichia coli coenzyme Q biosynthesis, is involved in aerobic C5-hydroxylation. | Hajj Chehade M, Loiseau L, Lombard M, Pecqueur L, Ismail A, Smadja M, Golinelli-Pimpaneau B, Mellot-Draznieks C, Hamelin O, Aussel L, Kieffer-Jaquinod S, Labessan N, Barras F, Fontecave M, Pierrel F | 2013 Jul 5 | 23709220 |
| Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene. | Kwon O, Kotsakis A, Meganathan R | 2000 May 15 | 10802164 |