EC number:1.14.13.242
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.242 |
|---|---|
| Description: | 3-hydroxy-2-methylpyridine-5-carboxylate monooxygenase. |
| Alternative Name: |
MHPCO. Methylhydroxypyridinecarboxylate oxidase. Methylhydroxypyridine carboxylate dioxygenase. 3-hydroxy-2-methylpyridinecarboxylate dioxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.242 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.242 |
| KEGG Enzyme Link: | KEGG1.14.13.242 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.242 |
| ExPASy Enzyme Link: | ExPASy1.14.13.242 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.242 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.242 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.242 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.242 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.242 |
EC number:1.14.13.242
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10864 | 3-hydroxy-2-methylpyridine-5-carboxylate + NADPH + O2 = 2-(acetamidomethylene)succinate + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[n;H0;+0:12]:[c;H0;+0:13](-[*:14]):[c;H0;+0:15](-[OH;+0:16]):[cH;+0:17]:1.[O;H0;+0:18]=[O;H0;+0:19]>>[*:9]-[C;H0;+0:10](-[CH2;+0:17]-[C;H0;+0:15](=[O;H0;+0:16])-[OH;+0:19])=[CH;+0:11]-[NH;+0:12]-[C;H0;+0:13](-[*:14])=[O;H0;+0:18].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring. | Sparrow LG, Ho PP, Sundaram TK, Zach D, Nyns EJ, Snell EE | 1969 May 25 | 4306031 |
| RHEA:10860 | 3-hydroxy-2-methylpyridine-5-carboxylate + NADH + O2 = 2-(acetamidomethylene)succinate + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[cH;+0:11]:[n;H0;+0:12]:[c;H0;+0:13](-[*:14]):[c;H0;+0:15](-[OH;+0:16]):[cH;+0:17]:1.[O;H0;+0:18]=[O;H0;+0:19]>>[*:9]-[C;H0;+0:10](-[CH2;+0:17]-[C;H0;+0:15](=[O;H0;+0:16])-[OH;+0:19])=[CH;+0:11]-[NH;+0:12]-[C;H0;+0:13](-[*:14])=[O;H0;+0:18].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1 |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The bacterial oxidation of vitamin B6. VII. Purification, properties, and mechanism of action of an oxygenase which cleaves the 3-hydroxypyridine ring. | Sparrow LG, Ho PP, Sundaram TK, Zach D, Nyns EJ, Snell EE | 1969 May 25 | 4306031 |