EC number:1.14.13.32
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.32 |
|---|---|
| Description: | Albendazole monooxygenase. |
| Alternative Name: |
Albendazole sulfoxidase. Albendazole monooxygenase (flavin-containing). |
| Cath: | 1.10.630.10; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.32 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.32 |
| KEGG Enzyme Link: | KEGG1.14.13.32 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.32 |
| ExPASy Enzyme Link: | ExPASy1.14.13.32 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.32 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.32 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.32 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.32 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.32 |
EC number:1.14.13.32
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:10796 | albendazole + H(+) + NADPH + O2 = albendazole S-oxide + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[S;H0;+0:10]-[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:9]-[S;H0;+0:10](-[*:11])=[O;H0;+0:13].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Sulfoxidation of albendazole by a cytochrome P450-independent monooxygenase from rat liver microsomes. | Fargetton X, Galtier P, Delatour P | 1986 Jul | 3739217 |
| Chiral sulfoxidation of albendazole by the flavin adenine dinucleotide-containing and cytochrome P450-dependent monooxygenases from rat liver microsomes. | Moroni P, Buronfosse T, Longin-Sauvageon C, Delatour P, Benoit E | 1995 Feb | 7736906 |
| Relative contribution of cytochromes P-450 and flavin-containing monoxygenases to the metabolism of albendazole by human liver microsomes. | Rawden HC, Kokwaro GO, Ward SA, Edwards G | 2000 Apr | 10759686 |