EC number:1.14.13.38

Enzyme

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     1. Oxidoreductases
        1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
            1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
ID:1.14.13.38
Description:Anhydrotetracycline 6-monooxygenase.
Alternative Name: ATC oxygenase.
Anhydrotetracycline oxygenase.
Anhydrotetracycline monooxygenase.

3D structure

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PDB

References

External Links

UniProtKB Enzyme Link: UniProtKB 1.14.13.38
BRENDA Enzyme Link: BRENDA 1.14.13.38
KEGG Enzyme Link: KEGG1.14.13.38
BioCyc Enzyme Link: BioCyc 1.14.13.38
ExPASy Enzyme Link: ExPASy1.14.13.38
EC2PDB Enzyme Link: EC2PDB 1.14.13.38
ExplorEnz Enzyme Link: ExplorEnz 1.14.13.38
PRIAM enzyme-specific profiles Link: PRIAM 1.14.13.38
IntEnz Enzyme Link: IntEnz 1.14.13.38
MEDLINE Enzyme Link: MEDLINE 1.14.13.38

EC number:1.14.13.38

MSA:

1.14.13.38;
Phylogenetic Tree:

1.14.13.38;
Uniprot:
M-CSA:
RHEA:11976 anhydrotetracycline + H(+) + NADPH + O2 = 5a,11a-dehydrotetracycline + H2O + NADP(+)
RULE(radius=1) [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]-[c;H0;+0:10]1:[c;H0;+0:11](-[OH;+0:12]):[*:13]:[*:14]:[c;H0;+0:15](-[*:16]):[c;H0;+0:17]:1-[*:18].[H+;H0:19].[O;H0;+0:20]=[O;H0;+0:21]>>[*:9]-[C;H0;+0:10]1=[C;H0;+0:17](-[*:18])-[C;H0;+0:15](-[*:16])(-[OH;+0:20])-[*:14]:[*:13]-[C;H0;+0:11]-1=[O;H0;+0:12].[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[OH2;+0:21]
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References

TitleAuthorsDatePubMed ID
Ablation of the otcC gene encoding a post-polyketide hydroxylase from the oxytetracyline biosynthetic pathway in Streptomyces rimosus results in novel polyketides with altered chain length.Peric-Concha N, Borovicka B, Long PF, Hranueli D, Waterman PG, Hunter IS2005 Nov 1116148009