EC number:1.14.13.39
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.39 |
|---|---|
| Description: | Nitric-oxide synthase (NADPH). |
| Alternative Name: |
NO synthase. Nitric-oxide synthetase. NADPH-diaphorase. Endothelium-derived relaxing factor synthase. Endothelium-derived relaxation factor-forming enzyme. |
| Cath: | 1.20.5.1720; 3.40.50.80; 3.90.1230.10; 3.90.340.10; 3.90.440.10; 1.20.990.10; 2.30.42.10; 2.40.30.10; 3.40.50.360; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.39 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.39 |
| KEGG Enzyme Link: | KEGG1.14.13.39 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.39 |
| ExPASy Enzyme Link: | ExPASy1.14.13.39 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.39 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.39 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.39 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.39 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.39 |
EC number:1.14.13.39
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:19897 | H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[NH2;+0:3])=[NH;+0:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[C;H0;+0:2](-[NH2;+0:4])=[O;H0;+0:14].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[NH;+0:3]=[O;H0;+0:15].[OH2;+0:16].[OH2;+0:17] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Characterization of a nitric oxide synthase from the plant kingdom: NO generation from the green alga Ostreococcus tauri is light irradiance and growth phase dependent. | Foresi N, Correa-Aragunde N, Parisi G, Caló G, Salerno G, Lamattina L | 2010 Nov | 21119059 |
| NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum. | Agapie T, Suseno S, Woodward JJ, Stoll S, Britt RD, Marletta MA | 2009 Sep 22 | 19805284 |
| Bacterial nitric-oxide synthases operate without a dedicated redox partner. | Gusarov I, Starodubtseva M, Wang ZQ, McQuade L, Lippard SJ, Stuehr DJ, Nudler E | 2008 May 9 | 18316370 |
| Bacterial flavodoxins support nitric oxide production by Bacillus subtilis nitric-oxide synthase. | Wang ZQ, Lawson RJ, Buddha MR, Wei CC, Crane BR, Munro AW, Stuehr DJ | 2007 Jan 26 | 17127770 |
| N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. | Stuehr DJ, Kwon NS, Nathan CF, Griffith OW, Feldman PL, Wiseman J | 1991 Apr 5 | 1706713 |
| Direct evidence for nitric oxide production by a nitric-oxide synthase-like protein from Bacillus subtilis. | Adak S, Aulak KS, Stuehr DJ | 2002 May 3 | 11856757 |
| Oxygen reduction by nitric-oxide synthases. | Stuehr D, Pou S, Rosen GM | 2001 May 4 | 11279231 |