EC number:1.14.13.54
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.54 |
|---|---|
| Description: | Ketosteroid monooxygenase. |
| Alternative Name: |
Steroid-ketone monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.54 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.54 |
| KEGG Enzyme Link: | KEGG1.14.13.54 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.54 |
| ExPASy Enzyme Link: | ExPASy1.14.13.54 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.54 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.54 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.54 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.54 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.54 |
EC number:1.14.13.54
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:11700 | H(+) + NADPH + O2 + progesterone = H2O + NADP(+) + testosterone acetate |
| RULE(radius=1) | [*:1]-[CH;+0:2](-[*:3])-[C;H0;+0:4](=[*:5])-[*:6].[*:7]-[N;H0;+0:8]1-[CH;+0:9]=[C;H0;+0:10](-[*:11])-[CH2;+0:12]-[CH;+0:13]=[CH;+0:14]-1.[H+;H0:15].[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[CH;+0:2](-[*:3])-[O;H0;+0:17]-[C;H0;+0:4](=[*:5])-[*:6].[*:7]-[n+;H0:8]1:[cH;+0:9]:[c;H0;+0:10](-[*:11]):[cH;+0:12]:[cH;+0:13]:[cH;+0:14]:1.[OH2;+0:16] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone. | Itagaki E | 1986 Mar | 3486864 |
| Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization. | Itagaki E | 1986 Mar | 3486863 |
| RHEA:19561 | androst-4-ene-3,17-dione + H(+) + NADPH + O2 = H2O + NADP(+) + testololactone |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[C;H0;+0:5](-[*:6])=[*:7].[*:8]-[N;H0;+0:9]1-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[CH2;+0:13]-[CH;+0:14]=[CH;+0:15]-1.[H+;H0:16].[O;H0;+0:17]=[O;H0;+0:18]>>[*:1]-[C;H0;+0:2](-[*:3])(-[*:4])-[O;H0;+0:17]-[C;H0;+0:5](-[*:6])=[*:7].[*:8]-[n+;H0:9]1:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[OH2;+0:18] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone. | Itagaki E | 1986 Mar | 3486864 |
| Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization. | Itagaki E | 1986 Mar | 3486863 |
| RHEA:21628 | 17alpha-hydroxyprogesterone + NADPH + O2 = acetate + androst-4-ene-3,17-dione + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[C;H0;+0:2](-[*:3])(-[OH;+0:4])-[C;H0;+0:5](=[*:6])-[*:7].[*:8]-[N;H0;+0:9]1-[CH;+0:10]=[C;H0;+0:11](-[*:12])-[CH2;+0:13]-[CH;+0:14]=[CH;+0:15]-1.[O;H0;+0:16]=[O;H0;+0:17]>>[*:1]-[C;H0;+0:2](-[*:3])=[O;H0;+0:4].[*:8]-[n+;H0:9]1:[cH;+0:10]:[c;H0;+0:11](-[*:12]):[cH;+0:13]:[cH;+0:14]:[cH;+0:15]:1.[*:6]=[C;H0;+0:5](-[*:7])-[OH;+0:16].[OH2;+0:17] |
| Reaction |  |
| Core-to-Core | |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Oxygenative lactonization of androstenedione to testololactone. | Itagaki E | 1986 Mar | 3486864 |
| Studies on steroid monooxygenase from Cylindrocarpon radicicola ATCC 11011. Purification and characterization. | Itagaki E | 1986 Mar | 3486863 |