EC number:1.14.13.63
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.63 |
|---|---|
| Description: | 3-hydroxyphenylacetate 6-hydroxylase. |
| Alternative Name: |
3-hydroxyphenylacetate 6-monooxygenase. |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.63 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.63 |
| KEGG Enzyme Link: | KEGG1.14.13.63 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.63 |
| ExPASy Enzyme Link: | ExPASy1.14.13.63 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.63 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.63 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.63 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.63 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.63 |
EC number:1.14.13.63
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:22208 | 3-hydroxyphenylacetate + H(+) + NADH + O2 = H2O + homogentisate + NAD(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Novel phacB-encoded cytochrome P450 monooxygenase from Aspergillus nidulans with 3-hydroxyphenylacetate 6-hydroxylase and 3,4-dihydroxyphenylacetate 6-hydroxylase activities. | Ferrer-Sevillano F, Fernández-Cañón JM | 2007 Mar | 17189487 |
| Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction. | Mingot JM, Peñalva MA, Fernández-Cañón JM | 1999 May 21 | 10329644 |
| RHEA:22204 | 3-hydroxyphenylacetate + H(+) + NADPH + O2 = H2O + homogentisate + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| Novel phacB-encoded cytochrome P450 monooxygenase from Aspergillus nidulans with 3-hydroxyphenylacetate 6-hydroxylase and 3,4-dihydroxyphenylacetate 6-hydroxylase activities. | Ferrer-Sevillano F, Fernández-Cañón JM | 2007 Mar | 17189487 |
| Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction. | Mingot JM, Peñalva MA, Fernández-Cañón JM | 1999 May 21 | 10329644 |