EC number:1.14.13.7
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.7 |
|---|---|
| Description: | Phenol 2-monooxygenase (NADPH). |
| Alternative Name: |
Phenol o-hydroxylase. Phenol hydroxylase. |
| Cath: | 3.30.9.10; 3.50.50.60; 3.90.56.10; 2.30.110.10; 3.40.30.20; |
3D structure
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External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.7 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.7 |
| KEGG Enzyme Link: | KEGG1.14.13.7 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.7 |
| ExPASy Enzyme Link: | ExPASy1.14.13.7 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.7 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.7 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.7 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.7 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.7 |
EC number:1.14.13.7
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:17061 | H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2]1-[CH;+0:3]=[C;H0;+0:4](-[*:5])-[CH2;+0:6]-[CH;+0:7]=[CH;+0:8]-1.[*:9]:[cH;+0:10]:[*:11].[H+;H0:12].[O;H0;+0:13]=[O;H0;+0:14]>>[*:1]-[n+;H0:2]1:[cH;+0:3]:[c;H0;+0:4](-[*:5]):[cH;+0:6]:[cH;+0:7]:[cH;+0:8]:1.[*:9]:[c;H0;+0:10](:[*:11])-[OH;+0:13].[OH2;+0:14] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| The crystal structure of phenol hydroxylase in complex with FAD and phenol provides evidence for a concerted conformational change in the enzyme and its cofactor during catalysis. | Enroth C, Neujahr H, Schneider G, Lindqvist Y | 1998 May 15 | 9634698 |
| Phenol hydroxylase from yeast. Sulfhydryl groups in phenol hydroxylase from Trichosporon cutaneum. | Neujahr HY, Gaal A | 1975 Oct 15 | 810352 |
| Phenol hydroxylase from yeast. Purification and properties of the enzyme from Trichosporon cutaneum. | Neujahr HY, Gaal A | 1973 Jun | 4146224 |