EC number:1.14.13.8
Enzyme
Download| EC Tree |
| 1. Oxidoreductases |
| 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen |
| 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor |
| ID: | 1.14.13.8 |
|---|---|
| Description: | Flavin-containing monooxygenase. |
| Alternative Name: |
Ziegler's enzyme. N,N-dimethylaniline monooxygenase. Mixed-function amine oxidase. Methylphenyltetrahydropyridine N-monooxygenase. FMO. Flavin monooxygenase. Flavin mixed function oxidase. FAD-containing monooxygenase. DMA oxidase. Dimethylaniline oxidase. Dimethylaniline N-oxidase. Dimethylaniline monooxygenase (N-oxide-forming). |
| Cath: | 3.50.50.60; |
3D structure
Click one PDB to see exact 3D structure provided by NGL.
Note: Use your mouse to drag, rotate, and zoom in and out of the structure. Mouse-over to identify atoms and bonds. Mouse controls documentation.References
External Links
| UniProtKB Enzyme Link: | UniProtKB 1.14.13.8 |
| BRENDA Enzyme Link: | BRENDA 1.14.13.8 |
| KEGG Enzyme Link: | KEGG1.14.13.8 |
| BioCyc Enzyme Link: | BioCyc 1.14.13.8 |
| ExPASy Enzyme Link: | ExPASy1.14.13.8 |
| EC2PDB Enzyme Link: | EC2PDB 1.14.13.8 |
| ExplorEnz Enzyme Link: | ExplorEnz 1.14.13.8 |
| PRIAM enzyme-specific profiles Link: | PRIAM 1.14.13.8 |
| IntEnz Enzyme Link: | IntEnz 1.14.13.8 |
| MEDLINE Enzyme Link: | MEDLINE 1.14.13.8 |
EC number:1.14.13.8
| MSA: | |
|---|---|
| Phylogenetic Tree: | |
| Uniprot: | |
| M-CSA: |
| RHEA:24468 | H(+) + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP(+) |
| RULE(radius=1) | [*:1]-[N;H0;+0:2](-[*:3])-[*:4].[*:5]-[N;H0;+0:6]1-[CH;+0:7]=[C;H0;+0:8](-[*:9])-[CH2;+0:10]-[CH;+0:11]=[CH;+0:12]-1.[H+;H0:13].[O;H0;+0:14]=[O;H0;+0:15]>>[*:1]-[N+;H0:2](-[*:3])(-[*:4])-[OH;+0:14].[*:5]-[n+;H0:6]1:[cH;+0:7]:[c;H0;+0:8](-[*:9]):[cH;+0:10]:[cH;+0:11]:[cH;+0:12]:1.[OH2;+0:15] |
| Reaction |  |
| Core-to-Core |
References
| Title | Authors | Date | PubMed ID |
|---|---|---|---|
| N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the rat liver flavin-containing monooxygenase expressed in yeast cells. | Chiba K, Kobayashi K, Itoh K, Itoh S, Chiba T, Ishizaki T, Kamataki T | 1995 May 26 | 7672012 |
| Reactions of the 4a-hydroperoxide of liver microsomal flavin-containing monooxygenase with nucleophilic and electrophilic substrates. | Jones KC, Ballou DP | 1986 Feb 25 | 3949735 |
| Characterization of hepatic microsomal metabolism as an in vivo detoxication pathway of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. | Chiba K, Kubota E, Miyakawa T, Kato Y, Ishizaki T | 1988 Sep | 3262153 |
| Human flavin-containing monooxygenases. | Cashman JR, Zhang J | 2006 | 16402899 |